Synthesis and evaluation of airway targeted PLGA nanoparticles for drug delivery in obstructive lung diseases.
Synthesis and evaluation of airway targeted PLGA nanoparticles for drug delivery in obstructive lung diseases.
复制标题
用于阻塞性肺疾病药物输送的气道靶向 PLGA 纳米颗粒的合成和评估。
DOI：
10.1007/978-1-61779-953-2_24
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Vij,Neeraj
中科院分区：
文献类型：
--
作者：
Vij,Neeraj
慢性气道炎症是慢性阻塞性气道疾病的标志，包括哮喘、COPD（慢性阻塞性肺病）和CF（囊性纤维化）。这也是纳米递送系统在这些慢性气道病症中的递送和治疗功效的主要挑战，因为纳米颗粒（NP）需要绕过气道防御机制，如我们最近讨论的。能够克服气道防御机制的NP应该允许靶向药物递送到疾病细胞。在过去的十年中，人们对开发用于癌症的靶向纳米颗粒的兴趣越来越大，但在设计用于治疗慢性炎症和阻塞性气道疾病的新型系统方面的努力相对较少。在这里，我们描述了制备用于靶向递送至气道中的特定细胞类型的载药多功能纳米颗粒的方法。本文讨论的用于选择性药物递送的制剂和方法目前在我们的实验室中处于临床前开发中，用于治疗慢性气道疾病，例如COPD、CF和哮喘。
Chronic airway inflammation is a hallmark of chronic obstructive airway diseases, including asthma, COPD (chronic obstructive pulmonary disease), and CF (cystic fibrosis). It is also a major challenge in delivery and therapeutic efficacy of nano-based delivery systems in these chronic airway conditions as nanoparticle (NP) need to bypass airways defense mechanisms as we recently discussed. NPs which are capable of overcoming airways defense mechanisms should allow targeted drug delivery to disease cells. Over the last decade there has been increasing interest in development of targeted NPs for cancer but relatively little effort on designing novel systems for treating chronic inflammatory and obstructive airway conditions. Here we describe methods for preparing drug loaded multifunctional nanoparticles for targeted delivery to specific cell types in airways. The formulations and methods for selective drug delivery, discussed here are currently under preclinical development in our laboratory for treating chronic airway conditions such as COPD, CF, and asthma.