Pregnancy-Associated Hypertension and Offspring Cardiometabolic Health
Pregnancy-Associated Hypertension and Offspring Cardiometabolic Health
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DOI：
10.1097/aog.0000000000002433
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发表时间：
2018-02-01
影响因子：
7.2
通讯作者：
Blackwell, Sean C.
中科院分区：
文献类型：
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作者：
Rice, Madeline Murguia;Landon, Mark B.;Blackwell, Sean C.
目的：评估妊娠相关高血压（妊娠期高血压和先兆子痫）是否与年轻后代的心脏代谢健康相关。方法：这是一项2012年至2013年的前瞻性观察性随访研究，研究对象是先前参加轻度妊娠期糖尿病治疗试验或非妊娠期糖尿病观察性研究的妇女所生的儿童。在出生后5-10年，儿童进行了检查，并获得空腹血液样本，以确定以下心脏代谢的危险因素：血压（BP），高密度脂蛋白胆固醇，甘油三酯，葡萄糖，胰岛素抵抗，腰围和体重指数（BMI）的稳态模型评估。23例（2%）高血压妊娠早产，73例（7%）高血压妊娠足月出生，58例（6%）血压正常妊娠早产，825例（84%）血压正常妊娠足月出生（参考组）。校正混杂因素后，与血压正常的母亲足月出生的儿童相比，患有妊娠相关性高血压的母亲足月出生的儿童的平均校正收缩压显著更高（收缩压104 mm Hg，95% CI 101-106 vs收缩压99 mm Hg，95% CI 99-100，P=.001）。没有其他显着差异observed.CONCLUSION：妊娠相关的高血压的妇女谁提供在任期内与较高的收缩压在后代，但不与他们的措施舒张压，体重指数，腰围，稳态模型评估胰岛素抵抗，血糖，或血脂。
OBJECTIVE: To evaluate whether pregnancy-associated hypertension (gestational hypertension and preeclampsia) was associated with the cardiometabolic health of young offspring.METHODS: This was a prospective observational follow-up study from 2012 to 2013 of children born to women previously enrolled in a mild gestational diabetes mellitus treatment trial or nongestational diabetes mellitus observational study. At 5-10 years after birth, children were examined and fasting blood samples obtained to determine the following cardiometabolic risk factors: blood pressure (BP), high-density lipoprotein cholesterol, triglycerides, glucose, homeostatic model assessment of insulin resistance, waist circumference, and body mass index (BMI).RESULTS: This analysis included 979 children evaluated at a median 7 years of age. Twenty-three (2%) were born preterm from a hypertensive pregnancy, 73 (7%) were born at term from a hypertensive pregnancy, 58 (6%) were born preterm from a normotensive pregnancy, and 825 (84%) were born at term from a normotensive pregnancy (reference group). After adjusting for confounding factors, mean adjusted systolic BP was significantly higher in the children who were born at term to mothers who experienced pregnancy-associated hypertension compared with those born at term to normotensive mothers (systolic BP of 104 mm Hg, 95% CI 101-106 vs systolic BP of 99 mm Hg, 95% CI 99-100, P=.001). No other significant differences were observed.CONCLUSION: Pregnancy-associated hypertension in women who deliver at term was associated with higher systolic BP in the offspring, but not with their measures of diastolic BP, BMI, waist circumference, homeostatic model assessment of insulin resistance, glucose, or lipids.