Changes in aortic distensibility and pulse wave velocity assessed with magnetic resonance imaging following beta-blocker therapy in the Marfan syndrome
Changes in aortic distensibility and pulse wave velocity assessed with magnetic resonance imaging following beta-blocker therapy in the Marfan syndrome
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DOI：
10.1016/s0002-9149(98)00315-4
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发表时间：
1998-07-15
影响因子：
2.8
通讯作者：
van der Wall, EE
中科院分区：
文献类型：
--
作者：
Groenink, M;de Roos, A;van der Wall, EE
已有研究表明，β-肾上腺素能阻滞剂可降低马凡综合征患者的主动脉根部扩张速度和主动脉并发症的发生。这可能是由于β-受体阻滞剂引起的主动脉僵硬的改变，其扩张性和脉搏波速度是体内可测量的衍生品。我们应用磁共振成像(MRI)结合臂动脉血压测量，研究了6名马凡综合征患者和6名健康志愿者在接受β-受体阻滞剂治疗2周后，4个水平的主动脉扩张性和沿整个主动脉的脉搏波速度的变化。洗澡组的平均血压显著降低(马凡：86+/-6vs 78+/-5 mm Hg，p
It has been shown that p-adrenergic blocking agents may reduce the rate of aortic root dilation and the development of aortic complications in patients with the Marfan syndrome. This may be due to beta-blocker-induced changes in aortic stiffness, of which distensibility and pulse wave velocity are in vivo measurable derivatives. We studied changes in distensibility at 4 levels of the aorta and pulse wave velocity along the entire aorta after 2 weeks of beta-blocker therapy in 6 Marfan syndrome patients and in 6 healthy volunteers, using magnetic resonance imaging (MRI) combined with brachial artery blood pressure measurements. In bath groups, mean blood pressure decreased significantly (Marfan: 86 +/- 6 vs 78 +/- 5 mm Hg, p