Alterations in local cerebral glucose utilization produced by D3 dopamine receptor-selective doses of 7-OH-DPAT and nafadotride.
Alterations in local cerebral glucose utilization produced by D3 dopamine receptor-selective doses of 7-OH-DPAT and nafadotride.
复制标题
D3 多巴胺受体选择性剂量的 7-OH-DPAT 和 nafadotride 引起局部脑葡萄糖利用的改变。
DOI：
10.1016/s0006-8993(98)00924-x
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发表时间：
1998
期刊：
影响因子：
2.9
通讯作者：
Pazdernik,TL
中科院分区：
文献类型：
--
作者：
Levant,B;Cross,RS;Pazdernik,TL
The D3dopamine receptor, localized primarily in limbic brain areas, is a potential antipsychotic site. The effects of D3receptor stimulation or blockade on neuronal activity were determined using the [14C ] -2-deoxyglucose method. Freely-moving, adult, male, Sprague–Dawley rats were injected s.c. with saline, agonist 7-hydroxy-diphenylaminotetralin (7-OH-DPAT) (0.1 mg/kg), or antagonist l-nafadotride (1 mg/kg). These doses of 7-OH-DPAT and l-nafadotride are behaviorally active and are 10-fold lower than a dose producing significant in vivo occupancy of D2receptors. The [14C ] -2-deoxyglucose procedure was initiated 30 min after the administration of the test compound. The rate of local cerebral glucose utilization (LCGU) was determined by quantitative autoradiography. 7-OH-DPAT produced a significant increase in LCGU in the substantia nigra. l-Nafadotride produced significant increases in LCGU in several brain areas including the lateral preoptic area, lateral habenula, caudate, septal area, entorhinal cortex, and some thalamic and hypothalamic areas. These observations indicate that stimulation or blockade of D3receptors alters LCGU and that produces a unique pattern of alterations in LCGU suggestive of potential antipsychotic activity.
