Immersed-boundary-type models of intravascular platelet aggregation
Immersed-boundary-type models of intravascular platelet aggregation
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DOI：
10.1016/j.cma.2007.06.030
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发表时间：
2008-01-01
影响因子：
7.2
通讯作者：
Guy, Robert D.
中科院分区：
文献类型：
--
作者：
Fogelson, Aaron L.;Guy, Robert D.
在血液凝固过程中，血小板聚集体的形成在两个尺度上建模，采用了由佩斯金浸入边界法激发的思想。微观尺度模型跟踪单个血小板，它们与彼此和周围液体的机械相互作用，它们对化学活化剂的检测和反应，以及血小板之间和血小板与血管壁之间的内聚和粘附“链接”的形成。这些模型允许包含结合-解结合，血小板刺激-反应和血小板表面化学的详细机制。宏观尺度模型在血小板浓度和内聚和粘附连接的分布方面处理相同的相互作用，并可用于研究临床感兴趣的血管中的血小板聚集，包括冠状动脉和脑动脉。在这两种类型的模型中，血小板聚集体的发展仅通过不断变化的流体力密度来影响流体运动，因此，笛卡尔网格方法是求解模型方程的有效方法。(C) 2007 Elsevier B.V.版权所有
The formation of platelet aggregates during blood clotting is modeled on two scales using ideas motivated by Peskin's immersed boundary method. The microscopic scale models track individual platelets, their mechanical interactions with one another and the surrounding fluid, their detection of and response to chemical activators, and the formation of cohesive and adhesive 'links' between platelets and between platelets and the vascular wall. These models allow inclusion of detailed mechanisms of binding-unbinding, platelet stimulus-response, and chemistry on the platelets' surfaces. The macroscopic scale models treat the same interactions in terms of concentrations of platelets and distributions of cohesive and adhesive links, and can be used to study platelet aggregation in vessels of clinical interest including the coronary and cerebral arteries. In both types of model, the development of platelet aggregates affects the fluid motion only through an evolving fluid force density, and consequently, Cartesian grid methods are effective in solving the model equations. (C) 2007 Elsevier B.V. All rights reserved.