ASSIGNMENT OF THE HUMAN RENAL DIPEPTIDASE GENE (DPEP1) TO BAND Q24 OF CHROMOSOME-16
ASSIGNMENT OF THE HUMAN RENAL DIPEPTIDASE GENE (DPEP1) TO BAND Q24 OF CHROMOSOME-16
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DOI：
10.1159/000133263
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发表时间：
1992-01-01
期刊：
影响因子：
--
通讯作者：
ABE, T
中科院分区：
文献类型：
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作者：
NAKAGAWA, H;INAZAWA, J;ABE, T
肾二肽酶（DPEP 1）或脱氢肽酶-I（E.C.3.4.13.11）是一种水解多种二肽的肾膜酶。DPEP 1参与谷胱甘肽及其结合物的肾代谢，也负责β-内酰胺抗生素的水解。使用人DPEP 1 cDNA探针，我们通过原位杂交将人肾二肽酶基因定位于人16号染色体q24带。
Renal dipeptidase (DPEP 1) or dehydropeptidase-I (E.C.3.4.13.11) is a kidney membrane enzyme which hydrolyzes a variety of dipeptides. DPEP1 is implicated in the renal metabolism of glutathione and its conjugates and is also responsible for hydrolysis of beta-lactam antibiotics. Using a human DPEP1 cDNA probe, we mapped the human renal dipeptidase gene to human chromosome 16 at band q24 by in situ hybridization.