Hip Strength in Adults With Type 1 Diabetes is Associated With Age at Onset of Diabetes
Hip Strength in Adults With Type 1 Diabetes is Associated With Age at Onset of Diabetes
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DOI：
10.1016/j.jocd.2011.08.004
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发表时间：
2012-01-01
影响因子：
2.5
通讯作者：
Lenhard, M. James
中科院分区：
文献类型：
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作者：
Maser, Raelene E.;Kolm, Paul;Lenhard, M. James
我们调查了I型糖尿病的发病年龄与面积骨密度(ABMD)、骨强度估计和外径之间的关系。采用双能X线骨密度仪(DXA)对60例成人股骨近端的骨密度、轴向强度(横截面积[CSA])、弯曲强度(截面弹性系数[SM])和股骨近端窄颈、股骨粗隆、股骨近端的外径进行了测量。使用协方差分析(ANCOVA)来确定基于DXA的骨骼测量是否与发病年龄相关，以及这种关系是否因性别而不同。ANCOVA模型包括发病年龄、性别和发病年龄与性别的交互作用，以及当前年龄、病程、身高、瘦软组织质量和血红蛋白水平作为协变量。在以CsA、SM或外径为因变量的调整模型中，发病年龄(p<；0.0001)和性别(p<；0.0001)有统计学意义，没有交互作用。对于股骨干骨密度，性别交互作用有显著的发病年龄(p=0.0285)，女性发病较早与股骨干骨密度较低有关，而男性与此无关。这一发现表明，1型糖尿病发病较早与骨强度和外径的测量较低有关。
We investigated the association of age at onset of type I diabetes with areal bone mineral density (aBMD), estimates of bone strength, and outer diameter. Using dual-energy X-ray absorptiometry (DXA), aBMD, axial strength (cross-sectional area [CSA]), bending strength (section modulus [SM]), and outer diameter at the narrow neck, intertrochanter, and shaft of the proximal femur were determined for 60 adults. Analysis of covariance (ANCOVA) was used to determine if the DXA-based measures of bone were related to age at onset and if this relationship differed by gender. Age at onset, gender, and the interaction of age at onset by gender were included in the ANCOVA models along with current age, duration, height, lean soft tissue mass, and hemoglobin Ale as covariates. In the adjusted models with CSA, SM, or outer diameter as the dependent variable, age at onset (p < 0.01) and gender (p < 0.0001) were significant with no interaction. For shaft aBMD, there was a significant age at onset by gender interaction (p = 0.0285), where an earlier onset was associated with lower aBMD in the femoral shaft of females but not males. The findings suggest that an earlier onset of type 1 diabetes is associated with lower measures of bone strength and outer diameter.