Protective Adaptive Immunity Against Severe Acute Respiratory Syndrome Coronaviruses 2 (SARS-CoV-2) and Implications for Vaccines
Protective Adaptive Immunity Against Severe Acute Respiratory Syndrome Coronaviruses 2 (SARS-CoV-2) and Implications for Vaccines
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DOI：
10.7759/cureus.8399
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发表时间：
2020-06-01
影响因子：
1.2
通讯作者：
Lopez, Osvaldo J.
中科院分区：
文献类型：
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作者：
Manners, Christopher;Bautista, Erick Larios;Lopez, Osvaldo J.
严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）是一种新出现的人类冠状病毒，导致2019冠状病毒病（COVID-19），这是一种主要的呼吸道疾病，已成为全球大流行。全世界有数百万人正在遭受COVID-19的折磨，数十万感染者已经死亡。然而，更多感染了SARS-CoV-2的人没有症状，或者患有以干咳和轻度发烧为特征的轻度疾病。这种新的大流行对全球公共卫生构成威胁，采取干预措施防止SARS-CoV-2病毒的持续传播至关重要。为了评估预防和治疗策略，了解SARS-CoV-2的发病机制和免疫反应是必要的。在这篇综述中，我们重点介绍了这种新型冠状病毒引起的保护性适应性免疫反应，以及成功诱导最佳保护的疫苗的要求。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging human coronavirus responsible for coronavirus disease 2019 (COVID-19), a predominantly respiratory disease that has become a global pandemic. Millions of people worldwide are suffering from COVID-19, and hundreds of thousands of those infected have died. Nevertheless, many more people who have been infected with SARS-CoV-2 are asymptomatic or suffer a mild disease characterized by dry cough and mild fever. This new pandemic poses a threat to public health on a global scale, and an intervention to prevent continued spread of SARS-CoV-2 virus is of the utmost importance. To assess preventive and therapeutic strategies, it is imperative to understand the pathogenesis and immune response against SARS-CoV-2. In this review, we concentrate on the protective adaptive immune response elicited by this novel coronavirus as well as requirements for a successful vaccine inducing optimal protection.