The Association Between Alcohol and Reflux Esophagitis, Barrett's Esophagus, and Esophageal Adenocarcinoma
The Association Between Alcohol and Reflux Esophagitis, Barrett's Esophagus, and Esophageal Adenocarcinoma
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DOI：
10.1053/j.gastro.2008.12.005
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发表时间：
2009-03-01
期刊：
影响因子：
29.4
通讯作者：
Murray, Liam J.
中科院分区：
文献类型：
--
作者：
Anderson, Lesley A.;Cantwell, Marie M.;Murray, Liam J.
背景与目的：饮酒可能会增加胃食道疾病。反流症状，对食道粘膜造成损害，和/或促进癌变。然而，关于酒精与反流性食管炎、Barrett‘s食道和食管腺癌之间的联系的报道是相互矛盾的。方法：从230例反流性食管炎患者、224例Barrett‘s食管炎患者和227例食管炎患者中收集与饮酒有关的信息，年龄为21岁，访谈日期为5年。腺癌患者和260例频率匹配的人群对照。用Logistic回归分析比较3个病例组和对照组的饮酒情况，并对潜在的混杂因素进行了调整。结果：有胃食道反流症状的对照人群比无症状的对照人群在访谈前5年饮酒的可能性较小(优势比[OR]，0.44，0.20-0.99)。访谈前5年饮酒总量与反流性食管炎、Barrett‘s食管炎、食管腺癌无相关性(OR分别为1.26、0.78~2.05；OR分别为0.72、0.43~1.21；OR分别为0.75、0.46~1.22)。葡萄酒与反流性食管炎呈负相关(OR，0.45，0.27~0.75)。21岁时饮酒总量与反流性食管炎(OR，2.24，1.35~3.74)显著相关，与Barrett‘s食管炎或食管腺癌无关(OR，1.06，0.63~1.79，OR，1.27，0.77~2.10)。结论：成年早期饮酒可能导致反流性食管炎的发生。最近饮酒似乎不会增加患反流性食管炎、巴雷特氏食道或食管腺癌的风险。事实上，饮用葡萄酒可能会降低患这三种食道疾病的风险。
Background & Aims: Alcohol consumption may increase gastroesophageal. reflux symptoms, cause damage to the esophageal mucosa, and/or promote carcinogenesis. However, reports about the association between alcohol and reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma are conflicting. Methods: information relating to alcohol consumption, at age 21 and 5 years before the interview date, was collected from 230 reflux esophagitis, 224 Barrett's esophagus, and 227 esophageal. adenocarcinoma patients and 260 frequency-matche population controls. Logistic regression analyses were used to compare alcohol consumption in the 3 case groups to controls with adjustment for potential confounders. Results: Population controls reporting gastroesophageal reflux symptoms were less likely than controls without symptoms to drink alcohol 5 years before the interview date (odds ratio [OR], 0.44, 0.20-0.99). No associations were observed between total alcohol consumption 5 years before the interview date and reflux esophagitis, Barrett's esophagus, or esophageal adenocarcinoma (OR, 1.26, 0.78-2.05; OR, 0.72, 0.43-1.21; and OR, 0.75, 0.46-1.22, respectively). Wine was inversely associated with reflux esophagitis (OR, 0.45, 0.27-0.75). Total alcohol consumption at age 21 years was significantly associated with reflux esophagitis (OR, 2.24, 1.35-3.74) but not with Barrett's esophagus or esophageal adenocarcinoma (OR, 1.06, 0.63-1.79 and OR, 1.27, 0.77-2.10, respectively). Conclusions: Alcohol consumption in early adulthood may lead to the development of reflux esophagitis. More recent alcohol consumption does not appear to confer any increased risk of reflux esophagitis, Barrett's esophagus, or esophageal adenocarcinoma. In fact, wine consumption may reduce the risk of these 3 esophageal disorders.