Accelerated Spirometric Decline in New York City Firefighters With α1-Antitrypsin Deficiency
Accelerated Spirometric Decline in New York City Firefighters With α1-Antitrypsin Deficiency
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DOI：
10.1378/chest.10-0187
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发表时间：
2010-11-01
期刊：
影响因子：
9.6
通讯作者：
Prezant, David J.
中科院分区：
文献类型：
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作者：
Banauch, Gisela I.;Brantly, Mark;Prezant, David J.
背景：2001年9月11日，世界贸易中心（WTC）的倒塌造成了大规模的空气污染，导致纽约市消防部门（FDNY）救援人员的肺功能不同程度地下降。α(1)-抗胰蛋白酶（AAT）缺乏是阻塞性气道疾病的一个危险因素。方法：本前瞻性、纵向队列研究在2001年9月11日之后的头4年，调查了AAT缺乏对90名世贸中心暴露的FDNY救援人员调整后纵向肺活量变化（FEV1）的影响。具有蛋白酶抑制剂（Pi） Z杂合性的工人被认为是中度AAT缺陷。PiS纯合性或PiS杂合性无PiZ杂合性为轻度缺乏，PiM纯合性为正常。另一种情况是，如果工人的血清AAT是
Background: On September 11, 2001, the World Trade Center (WTC) collapse caused massive air pollution, producing variable amounts of lung function reduction in the New York City Fire Department (FDNY) rescue workforce. alpha(1)-Antitrypsin (AAT) deficiency is a risk factor for obstructive airway disease.Methods: This prospective, longitudinal cohort study of the first 4 years post-September 11, 2001, investigated the influence of AAT deficiency on adjusted longitudinal spirometric change (FEV1) in 90 FDNY rescue workers with WTC exposure. Workers with protease inhibitor (Pi) Z heterozygosity were considered moderately AAT deficient. PiS homozygosity or PiS heterozygosity without concomitant PiZ heterozygosity was considered mild deficiency, and PiM homozygosity was considered normal. Alternately, workers had low AAT levels if serum AAT was