Comprehensive Analysis of Steroid Biomarkers for Guiding Primary Aldosteronism Subtyping
Comprehensive Analysis of Steroid Biomarkers for Guiding Primary Aldosteronism Subtyping
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DOI：
10.1161/hypertensionaha.119.13866
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发表时间：
2020-01-01
期刊：
影响因子：
8.3
通讯作者：
Auchus, Richard J.
中科院分区：
文献类型：
--
作者：
Turcu, Adina F.;Wannachalee, Taweesak;Auchus, Richard J.
在原发性醛固酮增多症（PA）中，需要肾上腺静脉采血（AVS）来区分醛固酮的单侧来源和双侧来源，并且皮质醇用于AVS数据的解读，但皮质醇存在一些缺陷。在这项研究中，我们介绍了其他几种类固醇在PA分型中的作用，包括在AVS过程中以及在外周血清中的作用。我们纳入了2012年至2018年间在密歇根大学接受AVS的PA患者。我们使用质谱法同时定量测定肾上腺静脉（AV）和外周的17种类固醇，包括在基线状态以及给予促肾上腺皮质激素后。根据侧向化指数≥或<4来将PA分类为单侧或双侧。
Adrenal vein sampling (AVS) is required to distinguish unilateral from bilateral aldosterone sources in primary aldosteronism (PA), and cortisol is used for AVS data interpretation, but cortisol has several pitfalls. In this study, we present the utility of several other steroids in PA subtyping, both during AVS, as well as in peripheral serum. We included patients with PA who underwent AVS at University of Michigan between 2012 and 2018. We used mass spectrometry to simultaneously quantify 17 steroids in adrenal veins (AV) and periphery, both at baseline and after cosyntropin administration. PA was classified as unilateral or bilateral based on a lateralization index >= or