Psoriasis
Psoriasis
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DOI：
10.1101/cshperspect.a015354
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发表时间：
2014-08-01
影响因子：
5.4
通讯作者：
Nestle, Frank O.
中科院分区：
文献类型：
--
作者：
Di Meglio, Paola;Villanova, Federica;Nestle, Frank O.
牛皮癣是一种常见的慢性炎症性皮肤病，具有多种临床表型，是遗传、环境和免疫因素相互作用的结果。四十年来银屑病的临床和基础研究已经阐明了许多疾病的致病机制，并为有效的靶向治疗铺平了道路。在此，我们回顾了这一进展，并确定了未来的研究方向，这些方向是由更综合的研究方法支持的，旨在进一步改善患者的生活。
Psoriasis is a common chronic inflammatory skin disease with a spectrum of clinical phenotypes and results from the interplay of genetic, environmental, and immunological factors. Four decades of clinical and basic research on psoriasis have elucidated many of the pathogenic mechanisms underlying disease and paved the way to effective targeted therapies. Here, we review this progress and identify future directions of study that are supported by a more integrative research approach and aim at further improving the patients' life.