Design of endoperoxides with anti-Candida activity
Design of endoperoxides with anti-Candida activity
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DOI：
10.1016/j.bmc.2006.10.021
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发表时间：
2007-01-01
影响因子：
3.5
通讯作者：
Macreadie, Ian G.
中科院分区：
文献类型：
--
作者：
Avery, Thomas D.;Macreadie, Peter I.;Macreadie, Ian G.
报道了控制环氧内过氧化物 2 和 3 及其母体内过氧化物 I 的广泛抗真菌结构-活性关系。报道了它们对白色念珠菌的抑制活性以及对培养的哺乳动物细胞的溶血活性和/或生长抑制。该信息为进一步开发内过氧化物和环氧内过氧化物作为局部抗真菌剂提供了指导。 (c) 2006 Elsevier Ltd. 保留所有权利。
Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides I are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents. (c) 2006 Elsevier Ltd. All rights reserved.