Serotonin transporter binding in patients with mood disorders:: a PET study with [11C](+)McN5652
Serotonin transporter binding in patients with mood disorders:: a PET study with [11C](+)McN5652
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DOI：
10.1016/s0006-3223(01)01351-8
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发表时间：
2002-05-01
影响因子：
10.6
通讯作者：
Shibuya, H
中科院分区：
文献类型：
--
作者：
Ichimiya, T;Suhara, T;Shibuya, H
背景：多项研究表明血清素转运蛋白（5-HTT）参与情绪障碍的病理生理学。本研究的目的是使用正电子发射断层扫描 (PET) 检查情绪障碍患者的 5-HTT 结合是否发生改变。方法：13 名未服用或未服用抗抑郁药物的情绪障碍患者和 21 名年龄匹配的健康对照受试者参与了本研究。这些患者包括 7 名重度抑郁症 (MDD) 患者和 6 名双相情感障碍 (BD) 患者。使用 5-HTT 的选择性配体 [C-11](+)McN5652 进行正电子发射断层扫描。通过参考组织的图形方法对丘脑和中脑的摄取进行定量，并使用结合电位（BP）作为 5-HTT 结合指数。结果：与对照受试者相比，情绪障碍患者的丘脑结合电位显着增加，而中脑的 BP 在各组之间没有差异。亚组比较显示，MDD 患者的丘脑血压显着高于对照组。相对于对照受试者，合并患者的丘脑结合潜力高出约 22%，MDD 患者高出 23%。结论：这些发现可能表明情绪障碍患者的 5-HTT 可能发生改变。丘脑的功能异常可能与情绪障碍的病理生理学有关。
Background: Several lines of studies have suggested the involvement of serotonin transporter (5-HTT) in the pathophysiology of mood disorders. The aim of this study was to examine whether 5-HTT binding was altered in patients with mood disorders using positron emission tomography (PET).Methods: Thirteen antidepressant-naive or -free patients with mood disorders and 21 age-matched healthy control subjects participated in this study. The patients consisted of 7 with major depressive disorder (MDD) and 6 with bipolar disorder (BD). Positron emission tomography scans were performed using a selective ligand for 5-HTT, [C-11](+)McN5652. The uptake was quantified in the thalamus and midbrain by, graphical method with reference tissue, and binding potential (BP) was used for the index of 5-HTT binding.Results: Binding potential in the thalamus was significantly increased in patients with mood disorders as compared to control subjects, whereas BP in the midbrain did not differ between the groups. Subgroup comparison showed that MDD patients had significantly higher BP in the thalamus compared to control subjects. Binding potential of the thalamus was higher by approximately 22% in the combined patients and 23% in MDD patients relative to control subjects.Conclusions: These findings may suggest the possibility of altered 5-HTT in patients with mood disorders. Functional abnormality, in the thalamus may, be involved in the pathophysiology of mood disorders.