Is FCRL3 a new general autoimmunity gene?
Is FCRL3 a new general autoimmunity gene?
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DOI：
10.1016/j.humimm.2007.01.013
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发表时间：
2007-05-01
期刊：
影响因子：
2.7
通讯作者：
Chistiakov, Alexander P.
中科院分区：
文献类型：
--
作者：
Chistiakov, Dimitry A.;Chistiakov, Alexander P.
自身免疫是一个多步骤的致病过程，由于环境因素的有害影响，导致免疫耐受性的崩溃和诱导自身反应性免疫反应，从而使个体发生遗传易感。最近的发现解决了不同自身免疫性疾病之间共有的共同致病机制，并提示存在与一般自身免疫性相关的遗传位点，从而有助于几种自身免疫性疾病的易感性。到目前为止，已经确定了几个与全身自身免疫有关的基因座。FCRL3基因是近年来在日本发现与类风湿关节炎(RA)、自身免疫性甲状腺疾病和系统性红斑狼疮(SLE)等自身免疫性疾病显著相关的基因座之一。然而，对高加索人的研究未能证实该基因与类风湿性关节炎和系统性红斑狼疮有很强的相关性，因此，FCRL3在一般自身免疫中的假定作用受到质疑。在这篇综述中，我们讨论了FCRL3基因是否是一个新发现的导致自身免疫性疾病共同易感性的基因。
Autoimmunity is a multistep pathogenic process, which arises in genetically predisposing individuals as a result of the harmful influence of environmental factors causing the breakdown of immune tolerance and induction of self-reactive immune response. Recent findings resolved common pathogenic mechanisms shared between different autoimmune diseases and suggested for the existence of genetic loci that could be involved in general autommunity and hence contribute to susceptibility of several autoimmune diseases. To date, several loci responsible for general autoimmunity have been identified. The Fc receptor-like 3 (FCRL3) gene is one of those loci for which a significant association with a number of autoimmune diseases such as rheumatoid arthritis (RA), autoimmune thyroid disease, and systemic lupus erythematosus (SLE) has been recently shown in Japanese. However, studies in Caucasians failed to confirm a strong association of this gene with RA and SLE and therefore made questionable the putative role of FCRL3 in general autoimmunity. In this review, we discuss whether the FCRL3 gene is a newly discovered gene contributing to shared susceptibility between autoimmune diseases.