Long-term follow-up of extremely low birth weight infants with neonatal renal failure
Long-term follow-up of extremely low birth weight infants with neonatal renal failure
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DOI：
10.1007/s00467-003-1186-1
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发表时间：
2003-09-01
影响因子：
3
通讯作者：
Zilleruelo, G
中科院分区：
文献类型：
--
作者：
Abitbol, CL;Bauer, CR;Zilleruelo, G
回顾性研究了20例极低出生体重并在新生儿期发生急性肾功能衰竭的早产儿的长期结局，为期18年。进行性肾病患者与肾功能正常者进行比较。目前的平均年龄为7.5 ± 4.6岁（范围3.2-18.5岁）。9例患者显示肾功能恶化（低GFR组）。通过随机尿蛋白/肌酐比值（Up/c）确定的蛋白尿增加与肾功能恶化相关（r=0.8，1岁时P0.6 [100%灵敏度，75%阳性预测值（PPV），1岁时P0.6 mg/dl（75%灵敏度，80%PPV，P85百分位数（89%灵敏度，PPV 67%，P=0.03）。肾质量丢失和肾钙质沉着不是预后指标。本报告开始确定重要的临床参数，应导致更密切的监测和潜在的治疗干预措施，以保护肾功能，在不断增长的人口存活的低出生体重个体。
The long-term outcome of 20 preterm infants with extremely low birth weight and acute renal failure in the neonatal period was studied retrospectively over an 18-year period. Those with progressive renal disease are compared with those with normal renal function. Current mean age is 7.5+/-4.6 years (range 3.2-18.5 years). Nine patients showed deterioration in renal function (low GFR group). Increasing proteinuria, as determined by random urine protein/creatinine ratio (Up/c), correlated with deterioration in renal function (r=0.8, P0.6 at 1 year of age [100% sensitivity, 75% positive predictive value (PPV), P0.6 mg/dl at 1 year of age (75% sensitivity, 80% PPV, P85th percentile (89% sensitivity, PPV 67%, P=0.03). Loss of renal mass and nephrocalcinosis were not prognostic indicators. This report begins to identify important clinical parameters that should lead to closer surveillance and potential treatment interventions for preservation of renal function in a growing population of surviving low birth weight individuals.