Thalamocortical dysrhythmia:: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography
Thalamocortical dysrhythmia:: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography
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DOI：
10.1073/pnas.96.26.15222
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发表时间：
1999-12-21
影响因子：
11.1
通讯作者：
Mitra, PP
中科院分区：
文献类型：
--
作者：
Llinás, RR;Ribary, U;Mitra, PP
在清醒、健康的人和患有神经源性疼痛、耳鸣、帕金森病或抑郁症的患者中，记录了自发的脑磁图活动。与对照组相比，患者表现出低频和节律性的增加，同时高频和低频振荡之间的连贯性普遍和显著增加。这些数据表明丘脑皮质节律失常的存在，我们认为这是上述所有情况的原因。这种连贯的活动是丘脑和皮质之间共振相互作用的结果，是由于丘脑细胞产生低阈值钙峰爆发。这些爆发波的出现与丘脑细胞超极化直接相关，超极化是由过度抑制或失易化引起的。阳性临床症状的出现被认为是异位伽马频段激活的结果，我们称之为“边缘效应”。这种效应是可以观察到的，因为低频和高频振荡之间的一致性增加，可能是由于大脑皮质水平上高频和低频丘脑皮质模块之间的抑制不对称造成的。
Spontaneous magnetoencephalographic activity was recorded in awake, healthy human controls and in patients suffering from neurogenic pain, tinnitus, Parkinson's disease, or depression. Compared with controls, patients showed increased low-frequency a rhythmicity, in conjunction with a widespread and marked increase of coherence among high- and low-frequency oscillations. These data indicate the presence of a thalamocortical dysrhythmia, which we propose is responsible for all the above mentioned conditions. This coherent a activity, the result of a resonant interaction between thalamus and cortex, is due to the generation of low-threshold calcium spike bursts by thalamic cells. The presence of these bursts is directly related to thalamic cell hyperpolarization, brought about by either excess inhibition or disfacilitation. The emergence of positive clinical symptoms is viewed as resulting from ectopic gamma-band activation, which we refer to as the "edge effect." This effect is observable as increased coherence between low- and high-frequency oscillations, probably resulting from inhibitory asymmetry between high- and low-frequency thalamocortical modules at the cortical level.