What proportion of episodes of gonorrhoea and chlamydia becomes symptomatic?
What proportion of episodes of gonorrhoea and chlamydia becomes symptomatic?
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DOI：
10.1258/0956462021924712
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发表时间：
2002-02-01
影响因子：
1.4
通讯作者：
Habbema, JDF
中科院分区：
文献类型：
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作者：
Korenromp, EL;Sudaryo, MK;Habbema, JDF
综合征治疗作为性病控制策略的有效性取决于出现症状的发作比例;很少有研究直接测量这一点。我们估计了淋病（NG）和衣原体（CT）的比例，综合了乌干达农村感染病例中自我报告的出院和排尿困难的点患病率、症状持续时间、潜伏期和无症状发作以及治疗对症状持续时间的影响。出现症状的发作比例估计为：NG男性45%，CT男性11%，NG女性14%，CT女性6%。这是平均1.5倍以上的症状流行率在横截面中感染病例在这一人口。估计值对无症状和有症状发作的相对持续时间的假设敏感，但总是与先前基于美国队列研究的直接估计值不一致。这些结果表明，在NG和CT发作中识别症状的概率在设置之间变化。在乌干达等治疗率低的人群中，这些概率可能非常低。在这方面，卫生教育应在性病管理方案中占有优先地位。
The effectiveness of syndromic treatment as an STD control strategy depends on the proportion of episodes which become symptomatic; few studies have measured this directly. We estimated these proportions for gonorrhoea (NG) and chlamydia (CT), synthesizing data on the point prevalence of self-reported discharge and dysuria among infected cases in rural Uganda, the durations of symptoms, incubation period and asymptomatic episodes, and the effect of treatment on symptom duration. Estimated proportions of episodes that become symptomatic were 45% for males with NG, 11% for males with CT, 14% for females with NG and 6% for females with CT. This was on average 1.5-fold higher than symptom prevalence at cross-section among infected cases in this population. Estimates were sensitive to assumptions on the relative durations of asymptomatic and symptomatic episodes, but were invariably inconsistent with previous direct estimates based on a US cohort study. These results show that the probability of recognizing symptoms in NG and CT episodes varies between settings. In populations with low treatment rates like Uganda, these probabilities can be very low. Here, health education should have priority in STD management programmes.