The myosin coiled-coil is a truly elastic protein structure
The myosin coiled-coil is a truly elastic protein structure
复制标题
DOI：
10.1038/nmat776
复制
发表时间：
2002-12-01
期刊：
影响因子：
41.2
通讯作者：
Rief, M
中科院分区：
文献类型：
--
作者：
Schwaiger, I;Sattler, C;Rief, M
Coiled-coils occur in a variety of proteins involved in mechanical and structural tasks in the cell. Their mechanical properties are important in various contexts ranging from hair elasticity to synaptic fusion. Beyond their importance in biology, coiled-coils have also attracted interest as programmable protein sequences for the design of novel hydrogels and materials. We have studied the elastic properties of the myosin coiled-coil at the single molecule level. The coiled-coil undergoes a massive structural transition at forces between 20 and 25 pN where the coil extends to about 2.5 times its original length. Unlike all other proteins investigated mechanically so far, this transition is reversible on a timescale of less than a second, making the coiled-coil a truly elastic protein.
