Acidity near eroding polylactide-polyglycolide in vitro and in vivo in rabbit tibial bone chambers.
Acidity near eroding polylactide-polyglycolide in vitro and in vivo in rabbit tibial bone chambers.
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DOI：
10.1016/s0142-9612(96)00075-0
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发表时间：
1996
期刊：
影响因子：
14
通讯作者：
C. Martin;H. Winet;J. Bao
中科院分区：
文献类型：
--
作者：
C. Martin;H. Winet;J. Bao
在骨腔胫骨植入物（BCl）中加载后，在体外和体内长期观察到聚（dl-丙交酯-共-乙交酯）（PDLLG）垫圈的腐蚀。使用植入兔的活体显微镜记录图像，并使用组合探针-参考微电极获得骨室中组织的直接pH值测量值。虽然在对照（未加载）和实验（携带PDLLG）BCl之间发现统计学显著的pH差异，但它们仅为0.2 pH单位的量级。该值被证明在生理学上无意义，因为检测到骨缺损愈合无统计学显著差异，如血管生成所示。结果表明，在PDLLG清洗器腐蚀期间测得的微小pH值变化将导致缓冲液是磷酸盐缓冲盐水，每周更换一次，还是组织液进行血管交换。
Eroding poly(dl-lactide-co-glycolide) (PDLLG) washers were observed chronically in vitro and in vivo following loading in a bone chamber tibial implant (BCl). Images were recorded using intravital microscopy of the implanted rabbit and direct pH measurements were obtained of the tissue in the bone chamber using a combination probe-reference microelectrode. While statistically significant pH differences were found between the control (unloaded) and experimental (PDLLG-bearing) BCls, they were only of the order of 0.2 pH units. This value proved to be physiologically insignificant as no statistically significant difference in bone defect healing, as indicated by angiogenesis, was detected. It was shown that the measured small pH changes during PDLLG washer erosion would result whether the buffer was phosphate-buffered saline replaced weekly or interstitial fluid subject to vascular exchanges.