The challenge of treating biofilm-associated bacterial infection
The challenge of treating biofilm-associated bacterial infection
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DOI：
10.1038/sj.clpt.6100247
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发表时间：
2007-08-01
影响因子：
6.7
通讯作者：
Patel, R.
中科院分区：
文献类型：
--
作者：
del Pozo, J. L.;Patel, R.
生物膜形成是许多亚急性和慢性细菌感染（包括异物相关感染）发病机制中的关键步骤。传统的抗菌剂很难根除生物膜。细菌生物膜具有多种潜在的抗菌药物耐药机制。抗菌素耐药机制可能同时起作用，并且在某些情况下甚至协同作用。持久细胞在生物膜细菌对抗菌药物的耐受性中发挥着重要作用。了解生物膜相关抗菌药物耐药性的机制是开发新治疗策略的关键。
Biofilm formation is a crucial step in the pathogenesis of many subacute and chronic bacterial infections, including foreign body-related infections. Biofilms are difficult to eradicate with conventional antimicrobial agents. Bacterial biofilms have several potential antimicrobial resistance mechanisms. Antimicrobial resistance mechanisms may act concurrently, and in some cases, synergistically. Persister cells play a major role in the tolerance of biofilm bacteria to antimicrobial agents. Understanding the mechanisms involved in biofilm-associated antimicrobial resistance is key to development of new therapeutic strategies.