Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study
Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study
复制标题
DOI：
10.1016/j.canep.2018.10.006
复制
发表时间：
2019-02-01
影响因子：
2.6
通讯作者：
Straif, Kurt
中科院分区：
文献类型：
--
作者：
Brenner, Darren R.;Fehringer, Gord;Straif, Kurt
背景：没有足够的证据来确定饮酒是否对肺癌风险有影响。我们对国际肺癌联盟和SYNERGY研究的数据进行了汇总分析，以调查饮料类型与其他潜在混杂因素的调整之间可能存在的关联。方法：21项病例对照研究和一项队列研究，其中包含从问卷中获得的酒精摄入数据汇总分析（19，149例病例和362，340例对照）。校正后的比值比（OR）或风险比（HR）与相应的95%置信区间（CI）进行了估计，每一个酒精消费的措施。在适当情况下，使用随机或固定效应模型合并效应估计值。协会进行了检查整体肺癌和组织学type.Results：我们观察到肺癌的总体风险和消费的酒精饮料相比，非饮酒者之间的负相关，但该协会不是单调的。观察到每天饮用10-19.9 g乙醇的人风险最低（OR vs.非饮酒者= 0.78; 95% CI：0.67，0.91），其中1杯饮料约为12-15 g。这种J形相关性在鳞状细胞癌（SCC）中最为突出。酒精饮料与所有肺癌的相关性几乎没有变化，但对于SCC有显着差异。我们观察到与啤酒摄入量（OR>= 20 g/天vs不饮酒者= 1.42; 95%CI：1.06，1.90）。结论：我们观察到的非单调关联或啤酒饮用与鳞状细胞癌之间的正相关是否反映了真实的影响，有待进一步分析和了解可能的生物学机制。
Background: There is inadequate evidence to determine whether there is an effect of alcohol consumption on lung cancer risk. We conducted a pooled analysis of data from the International Lung Cancer Consortium and the SYNERGY study to investigate this possible association by type of beverage with adjustment for other potential confounders.Methods: Twenty one case-control studies and one cohort study with alcohol-intake data obtained from questionnaires were included in this pooled analysis (19,149 cases and 362,340 controls). Adjusted odds ratios (OR) or hazard ratios (HR) with corresponding 95% confidence intervals (CI) were estimated for each measure of alcohol consumption. Effect estimates were combined using random or fixed-effects models where appropriate. Associations were examined for overall lung cancer and by histological type.Results: We observed an inverse association between overall risk of lung cancer and consumption of alcoholic beverages compared to non-drinkers, but the association was not monotonic. The lowest risk was observed for persons who consumed 10-19.9 g/day ethanol (OR vs. non-drinkers = 0.78; 95% CI: 0.67, 0.91), where 1 drink is approximately 12-15 g. This J-shaped association was most prominent for squamous cell carcinoma (SCC). The association with all lung cancer varied little by type of alcoholic beverage, but there were notable differences for SCC. We observed an association with beer intake (OR for >= 20 g/day vs nondrinker = 1.42; 95% CI: 1.06, 1.90).Conclusions: Whether the non-monotonic associations we observed or the positive association between beer drinking and squamous cell carcinoma reflect real effects await future analyses and insights about possible biological mechanisms.