Mutation caused by human phagocytes.
Mutation caused by human phagocytes.
复制标题
由人类吞噬细胞引起的突变。
作者：
S. Weitzman;T. Stossel
将鼠伤寒沙门氏菌TA100的组氨酸需要突变体与人外周血白细胞一起孵育。这些细菌中有更多的恢复到组氨酸的独立性比对照没有与细胞孵育。富含吞噬细胞的悬浮液具有致突变性，而慢性肉芽肿病患者的热灭活细胞、淋巴细胞或混合血白细胞则无致突变性。活性氧代谢产物的产生可以解释吞噬细胞诱导突变的能力。
Histidine-requiring mutants of Salmonella typhimurium TA100 were incubated with human peripheral blood leukocytes. More of these bacteria reverted to histidine independence than controls not incubated with cells. Phagocyte-rich suspensions were mutagenic, while heat-killed cells, lymphocytes, or mixed blood leukocytes of a patient with chronic granulomatous disease were not. Production of reactive oxygen metabolites could explain the capacity of phagocytes to induce mutation.