Peripheral blood monocyte count reflecting tumor-infiltrating macrophages is a predictive factor of adverse pathology in radical prostatectomy specimens
Peripheral blood monocyte count reflecting tumor-infiltrating macrophages is a predictive factor of adverse pathology in radical prostatectomy specimens
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DOI：
10.1002/pros.23398
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发表时间：
2017-10-01
期刊：
影响因子：
2.8
通讯作者：
Nonomura, Norio
中科院分区：
文献类型：
--
作者：
Hayashi, Takuji;Fujita, Kazutoshi;Nonomura, Norio
背景肿瘤浸润性巨噬细胞被认为来源于血液单核细胞，与肿瘤细胞相互作用，促进肿瘤进展。本研究的目的是评估外周血单核细胞计数与病理结果和局部肿瘤浸润巨噬细胞在乳腺癌切除术标本的关联。方法术前外周血单核细胞计数进行回顾性评估，其与病理结果的关联（病理T分期，Gleason评分，前列腺外扩展，精囊浸润，和手术切缘）和生化复发的248例患者接受根治性直肠癌切除术。结果前列腺外浸润、精囊浸润或原发性Gleason 4患者的外周血单核细胞计数显著高于无上述病理改变的患者（P
BackgroundTumor-infiltrating macrophages, which are thought to be derived from blood monocytes, interact with tumor cells to promote cancer progression. The aim of this study was to assess the association of peripheral blood monocyte count with pathological findings and local tumor-infiltrating macrophages in prostatectomy specimens.MethodsPreoperative peripheral blood monocyte counts were retrospectively assessed for their associations with pathological findings (pathological T stage, Gleason Score, extraprostatic extension, seminal vesicle invasion, and surgical margin) and biochemical recurrence of 248 patients who underwent radical prostatectomy. Local tumor-infiltrating macrophages were also evaluated immunohistochemically for their association with peripheral monocyte counts.ResultsThe peripheral monocyte counts of the patients with extraprostatic extension, seminal vesicle invasion, or primary Gleason 4 were significantly higher than those of the patients without each of these pathological findings (P