Cerium oxide nanoparticles in neuroprotection and considerations for efficacy and safety.
Cerium oxide nanoparticles in neuroprotection and considerations for efficacy and safety.
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DOI：
10.1002/wnan.1444
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Ehrich M
中科院分区：
文献类型：
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作者：
Rzigalinski BA;Carfagna CS;Ehrich M
氧化铈纳米颗粒在材料工业中有着广泛的应用，由于其强大的再生抗氧化性能，最近被考虑用于生物医学。鉴于大脑是人体中氧化程度最高的器官之一，它受到一些最高水平的氧化应激的影响，特别是在神经退行性疾病中。因此，氧化铈纳米颗粒目前正在研究几种神经退行性疾病的疗效，并显示出有希望的神经保护水平。本文综述了氧化铈纳米颗粒在神经退行性疾病中的应用基础及其可能的作用机制。本文综述了氧化铈纳米颗粒在神经退行性疾病动物模型体内工作的最新总结。此外，我们还研究了氧化铈纳米颗粒在体内的生物分布、毒性和安全性。最后，我们讨论了未来的发展方向，如果这种纳米药物要从实验台上升到床边。
Cerium oxide nanoparticles have widespread use in the materials industry, and have recently come into consideration for biomedical use due to their potent regenerative antioxidant properties. Given that the brain is one of the most highly oxidative organs in the body, it is subject to some of the greatest levels of oxidative stress, particularly in neurodegenerative disease. Therefore, cerium oxide nanoparticles are currently being investigated for efficacy in several neurodegenerative disorders and have shown promising levels of neuroprotection. This review discusses the basis for cerium oxide nanoparticle use in neurodegenerative disease and its hypothesized mechanism of action. The review focuses on an up-to-date summary of in vivo work with cerium oxide nanoparticles in animal models of neurodegenerative disease. Additionally, we examine the current state of information regarding biodistribution, toxicity, and safety for cerium oxide nanoparticles at the in vivo level. Finally, we discuss future directions that are necessary if this nanopharmaceutical is to move up from the bench to the bedside.