Partitioning and diffusion of parathion in human dermis.
Partitioning and diffusion of parathion in human dermis.
复制标题
对硫磷在人真皮中的分配和扩散。
DOI：
10.1016/j.ijpharm.2012.03.023
复制
发表时间：
2012
影响因子：
5.8
通讯作者：
Kasting,GeraldB
中科院分区：
文献类型：
--
作者：
Ibrahim,Rania;Kasting,GeraldB
一种先前开发的方法，采用透析膜与安装在并排扩散池中的人真皮组织串联使用，用于观察供体隔室中可溶性蛋白质的存在对测得的转运参数的影响。在透析膜的存在下，分配系数显着降低，扩散系数显着高于在其不存在下测定的那些;然而，差异小于先前测定的更高的蛋白结合化合物，双氯芬酸。结果表明，透析膜方法对于研究与真皮中可溶性蛋白质结合超过约87%的渗透物是重要的。结果进行了讨论的背景下，在人真皮的低分子量溶质的分区和运输的预测模型。
A previously developed method employing the use of a dialysis membrane in series with human dermis tissue mounted in side-by-side diffusion cells was utilized to observe the effects of the presence of soluble proteins in the donor compartment on the measured transport parameters of parathion. In the presence of the dialysis membrane the partition coefficient was significantly lower and the diffusion coefficient significantly higher than those determined in its absence; however, the difference was less than that previously determined for the more highly protein bound compound, diclofenac. The result suggests the dialysis membrane method is important for studying permeants that are more than about 87% bound to soluble proteins in the dermis. The results are discussed in the context of a predictive model for partitioning and transport of low molecular weight solutes in human dermis.