STATISTICAL DISTRIBUTIONS OF NUCLEOSOMES - NONRANDOM LOCATIONS BY A STOCHASTIC MECHANISM
STATISTICAL DISTRIBUTIONS OF NUCLEOSOMES - NONRANDOM LOCATIONS BY A STOCHASTIC MECHANISM
复制标题
DOI：
10.1093/nar/16.14.6677
复制
发表时间：
1988-07-25
影响因子：
14.9
通讯作者：
STRYER, L
中科院分区：
文献类型：
--
作者：
KORNBERG, RD;STRYER, L
推导了核小体在染色质中分布的表达式。核小体以大量染色质中的密度放置在DNA上，它们的位置可以随机变化。不需要进一步的假设来模拟各种核酸酶获得的消化周期模式。边界约束的引入，例如由于序列特定的蛋白质结合，导致在非随机位置产生规则间隔的核小体阵列，类似于一些基因和其他染色体区域报道的阵列。
Expressions are derived for distributions of nucleosomes in chromatin. Nucleosomes are placed on DNA at the densities found in bulk chromatin, and their locations are allowed to vary at random. No further assumptions are required to simulate the periodic patterns of digestion obtained with various nucleases. The introduction of a boundary constraint, due for example to sequence-specific protein binding, results in an array of regularly spaced nucleosomes at nonrandom locations, similar to the arrays reported for some genes and other chromosomal regions.