The pharmacology of inhibition of mitral cells in the olfactory bulb.
The pharmacology of inhibition of mitral cells in the olfactory bulb.
复制标题
抑制嗅球二尖瓣细胞的药理学。
DOI：
10.1016/0006-8993(71)90026-6
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发表时间：
1971
期刊：
影响因子：
2.9
通讯作者：
H. Mclennan
中科院分区：
文献类型：
--
作者：
H. Mclennan
在γ-氨基丁酸（GABA）、dl-同型半胱氨酸（DLH）或去甲肾上腺素附近，电泳应用可抑制嗅球二尖瓣细胞。GABA和去甲肾上腺素的作用可通过同时从另一电极筒中射出双球茎碱而可逆地消除；二尖瓣细胞附近的部分细胞被DLH和去甲肾上腺素兴奋。二尖瓣线可以减少二尖瓣细胞在侧嗅道条件反射时的反生理反应的抑制作用；然而，单次嗅道刺激后细胞放电的暂停时间被延长。结果表明：(a)颗粒细胞-二尖瓣细胞抑制可能是gaba介导的；(b)颗粒细胞接受兴奋性去肾上腺素能和抑制性gaba介导的输入。
Mitral cells of the olfactory bulb were inhibited by the electrophoretic application in their vicinity of γ-aminobutyrate (GABA),dl-homocysteate (DLH) or noradrenaline. The effects of GABA and of noradrenaline were reversibly abolished by the simultaneous ejection of bicuculline from another barrel of the electrode; that of DLH was changed to an excitation: some cells situated close to mitral cells were excited by DLH and by noradrenaline.The inhibition of the antidromic response of mitral cells by a conditioning volley in the lateral olfactory tract was reduced by bicuculline: however the pause in cell firing after a single olfactory tract stimulus was lengthened.The results suggest (a) that granule cell-mitral cell inhibition may be GABA-mediated; (b) that granule cells receive both excitatory noradrenergic and inhibitory GABA-mediated inputs.