Effect of Intravenous Ethanol on Capsaicin-Induced Hyperalgesia in Human Subjects
Effect of Intravenous Ethanol on Capsaicin-Induced Hyperalgesia in Human Subjects
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DOI：
10.1111/acer.13095
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发表时间：
2016-07-01
影响因子：
3.2
通讯作者：
Petrakis, Ismene L.
中科院分区：
文献类型：
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作者：
Arout, Caroline A.;Perrino, Albert C.;Petrakis, Ismene L.
背景本研究的目的是评估乙醇 (EtOH) 对健康参与者中辣椒素引起的痛觉过敏的影响。具体来说，我们研究了 3 种干预措施后辣椒素引起的痛觉过敏面积的变化：2 个目标呼吸酒精浓度 (BrAC) 的静脉注射乙醇，或安慰剂。方法 18 名参与者以随机顺序参加 3 个测试日。每个测试日，参与者在前臂掌侧表面皮内注射辣椒素，然后输注高浓度 EtOH（目标 BrAC=0.100g/dl）、低浓度 EtOH（目标 BrAC=0.040g/dl）或安慰剂。在 EtOH 输注之前和达到目标 BrAC 时再次通过 von Frey 技术在 2 个时间点测定痛觉过敏面积。主要结果是辣椒素引起的痛觉过敏面积的百分比变化。其他结果测量包括在每个时间点进行的情绪状态视觉模拟量表 (VAS)。结果输注高浓度 EtOH 后，辣椒素引起的痛觉过敏面积显着减少 30% (p
BackgroundThe objective of this study was to assess ethanol's (EtOH's) effects on capsaicin-induced hyperalgesia in healthy participants. Specifically, we investigated the change in area of capsaicin-induced hyperalgesia following 3 interventions: intravenous EtOH at 2 targeted breath alcohol concentrations (BrAC), or placebo.MethodsEighteen participants participated in 3 test days in a randomized order. Each test day, participants received an intradermal capsaicin injection on the volar surface of the forearm, followed by either infusion of high concentration EtOH (targeted BrAC=0.100g/dl), low concentration EtOH (targeted BrAC=0.040g/dl), or placebo. The area of hyperalgesia was determined by von Frey technique at 2 time points, prior to EtOH infusion, and again when target BrAC was reached. The primary outcome was the percent change in the area of capsaicin-induced hyperalgesia. Additional outcome measures included the visual analogue scale of mood states (VAS), which was administered at each time point.ResultsThere was a marked 30% reduction in the area of capsaicin-induced hyperalgesia with infusion of a high concentration of EtOH (p