Type-specific HPV infection and multiple HPV types: Prevalence and risk factor profile in nearly 12,000 younger and older Danish women
Type-specific HPV infection and multiple HPV types: Prevalence and risk factor profile in nearly 12,000 younger and older Danish women
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DOI：
10.1097/olq.0b013e31815ac5c7
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发表时间：
2008-03-01
影响因子：
3.1
通讯作者：
Iftner, Thomas
中科院分区：
文献类型：
--
作者：
Nielsen, Ann;Kjaer, Susanne Kruger;Iftner, Thomas
目的：人乳头瘤病毒（HPV）被认为是宫颈癌的必要原因。当前研究的目的是确定在实施HPV疫苗之前，随机抽样的丹麦妇女中HPV感染的负担。进一步，我们评估了流行的高危（HR） HPV感染和多种HR HPV感染的危险因素。方法：在目前的横断面研究中，我们使用了一项基于人群的队列研究的基线数据，其中参与者接受了访谈并进行了妇科检查。使用杂交捕获2对10544名20-29岁女性和1443名40-50岁女性的宫颈样本进行了HR HPV分析。采用LIPA进行基因分型。结果：20 ~ 29岁和40 ~ 50岁女性HR HPV患病率分别为17.9%和4.4%。HPV16是最常见的HR类型，在细胞学异常的女性中也是如此。多种HPV类型非常普遍，特别是在年轻人群中。终生性伴侣数量是HR HPV感染的主要危险因素（异性性伴侣数为0 = 15,OR = 2.8, OR = 3.4）。
Objectives: Human papillomavirus (HPV) is considered a necessary cause of cervical cancer. The aim of the current study was to determine the burden of HPV infection among randomly sampled Danish women before the vaccine against HPV is implemented. Further we assessed the risk factor profile for prevalent high risk (HR) HPV infection and infection with multiple HR HPV types.Methods: In the present cross-sectional study, we used baseline data from a population-based cohort study where participants were interviewed and had a gynecological examination. Cervical samples were analyzed for HR HPV using Hybrid capture 2 in 10,544 women aged 20-29 years and 1443 women aged 40-50 years. Genotyping was performed using LIPA.Results: The prevalence of HR HPV was 17.9% and 4.4% in women aged 20-29 years and 40-50 years, respectively. HPV16 was the most common HR type overall and among women with abnormal cytology. Multiple HPV types were highly prevalent, notably in the younger cohort. Lifetime number of sexual partners was the main risk factor for HR HPV infection (adj. OR = 2.8 and OR = 3.4 for >= 15 partners vs.