4-SUBSTITUTED-5,5-DIMETHYL OXAZOLIDIN-2-ONES AS EFFECTIVE CHIRAL AUXILIARIES FOR ENOLATE ALKYLATIONS AND MICHAEL ADDITIONS
4-SUBSTITUTED-5,5-DIMETHYL OXAZOLIDIN-2-ONES AS EFFECTIVE CHIRAL AUXILIARIES FOR ENOLATE ALKYLATIONS AND MICHAEL ADDITIONS
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DOI：
10.1016/0957-4166(95)00057-v
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发表时间：
1995-03-01
影响因子：
--
通讯作者：
SANGANEE, HJ
中科院分区：
文献类型：
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作者：
DAVIES, SG;SANGANEE, HJ
4-（甲基、苯基、苄基和异丙基）-5,5-二甲基-恶唑烷-2-酮，很容易从α-氨基酸中获得，被证明是立体选择性烯醇烷基化和连接的N-酰基部分的共轭加成的有效手性助剂。
4-(Methyl, phenyl, benzyl, and i-propyl)-5,5-dimethyl-oxazolidin-2-ones, readily available from alpha-amino acids, are shown to be effective chiral auxiliaries for stereoselective enolate alkylations and conjugate additions of attached N-acyl moieties.