A 6-Aminoquinolone Compound, WC5, with Potent and Selective Anti-Human Cytomegalovirus Activity
A 6-Aminoquinolone Compound, WC5, with Potent and Selective Anti-Human Cytomegalovirus Activity
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DOI：
10.1128/aac.00988-08
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发表时间：
2009-01-01
影响因子：
4.9
通讯作者：
Loregian, Arianna
中科院分区：
文献类型：
--
作者：
Mercorelli, Beatrice;Muratore, Giulia;Loregian, Arianna
We identified a 6-aminoquinolone compound, WC5, that inhibits human cytomegalovirus (HCMV) replication with a selectivity index of similar to 500. WC5 also showed activity against drug-resistant HCMV strains. In contrast, it did not significantly affect the replication of human herpesvirus 6 and 8 and was similar to 10-fold less active against murine cytomegalovirus. Thus, WC5 may represent a lead for the development of new, potent, and selective anti-HCMV compounds.
