CEREBRAL WHITE MATTER AND COGNITION IN HYDROCEPHALIC CHILDREN
CEREBRAL WHITE MATTER AND COGNITION IN HYDROCEPHALIC CHILDREN
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DOI：
10.1001/archneur.1992.00530320042010
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发表时间：
1992-08-01
影响因子：
--
通讯作者：
MINER, ME
中科院分区：
文献类型：
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作者：
FLETCHER, JM;BOHAN, TP;MINER, ME
尽管患有脑积水的儿童通常表现出与语言技能相比，非语言认知技能的发展较差，但人们对这些差异的神经病理相关性知之甚少。在本研究中，年龄匹配的脑膜膨出、脑膜膨出和导水管狭窄的儿童和正常人的磁共振图像测量了脑白质结构和侧脑室。同时测量言语和非言语认知技能时，每个侧脑室的体积以及胼胝体和内囊的横截面积都与此相关。脑膜脊液膨出组和导水管狭窄组的痂小体较小。所有患者组的侧脑室较大，内囊较小。半卵圆中心的大小无差异。虽然语言和非语言的测量结果与胼胝体的大小呈正相关，但非语言的测量结果的相关性更高。非语言测量与右侧侧脑室相关，但与左侧侧脑室无关，与左右内囊面积相关。言语测量与左侧侧脑室和左侧内囊相关，但与右侧相关，但与右侧相关。这些结果表明，胼胝体和认知技能之间的关系也受到侧脑室和其他脑白质束积水相关变化的影响。
Although children with hydrocephalus frequently show poor development of nonverbal cognitive skills relative to verbal skills, little is known about the neuropathologic correlates of these discrepancies. In this study, cerebral white-matter structures and lateral ventricles were measured from the magnetic resonance images of age-matched children with meningomyelocele, meningocele, and aqueductal stenosis and normal subjects. The volume of each lateral ventricle and the cross-sectional area of the corpus callosum and internal capsules were correlated with concurrent measures of verbal and nonverbal cognitive skills. The corpus callosum in the meningomyelocele and aqueductal stenosis groups was smaller. The lateral ventricles were larger, and the internal capsules were smaller, in all patient groups than in normal subjects. There were no differences in the size of the centra semiovale. Although verbal and nonverbal measures correlated positively with the size of the corpus callosum, the correlation was higher for nonverbal measures. Nonverbal measures correlated with the right, but not the left, lateral ventricle and with the area of the right and left internal capsules. Verbal measures correlated with the left, but not right, lateral ventricle and with the left, but not right, internal capsule. These results show a relationship between the corpus callosum and cognitive skills that is also influenced by hydrocephalus-related changes in the lateral ventricles and other cerebral white-matter tracts.