Effect of alcohol on the development of hepatocellular carcinoma in patients with hepatitis B virus-related cirrhosis: a cross-sectional case-control study.
Effect of alcohol on the development of hepatocellular carcinoma in patients with hepatitis B virus-related cirrhosis: a cross-sectional case-control study.
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DOI：
10.3350/kjhep.2010.16.3.308
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发表时间：
2010-09
期刊：
影响因子：
--
通讯作者：
Kim JH
中科院分区：
文献类型：
--
作者：
Kwon OS;Jung YK;Kim YS;Kim SG;Kim YS;Lee JI;Lee JW;Kim YS;Chun BC;Kim JH
酒精摄入是否会增加慢性乙型肝炎病毒（HBV）感染患者发生肝细胞癌（HCC）的风险仍存在争议。本研究的目的是确定酒精摄入对HCC发展的影响。2006年1月至2008年8月期间，在仁川地区3家主要医院住院的146名初步诊断为HCC的患者被纳入病例。另外146名年龄和性别相匹配的肝硬化患者被纳入对照组。所有病例和对照组均为HBsAg阳性，并有终生饮酒史。病例和对照组年龄分别为53±8岁和53±9岁（mean±SD），每组男性118人，女性28人。基础实验室数据、Child-Pugh类分布、HBeAg阳性（31.5%对37.7%）、HBV DNA水平（5.74±2.35对5.98±2.29 log10拷贝/mL）以及终生酒精摄入量超过292 kg的比例（30.8%对34.9%）在病例和对照组之间没有差异。两组男性患者的累积酒精摄入量和重度饮酒者的比例没有差异。酒精摄入可能不会增加HBV感染患者发生HCC的风险。
Whether alcohol intake increases the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection remains controversial. The aim of this study was to determine the effect of alcohol intake on the development of HCC. Between January 2006 and August 2008, 146 patients with an initial diagnosis of HCC who were hospitalized in 3 major hospitals in the Incheon area were enrolled as cases. Another 146 cirrhotic patients, who matched the cases by age and sex, were enrolled as controls. All cases and controls were HBsAg positive, and had a history of lifetime alcohol intake. The cases and controls were aged 53±8 and 53±9 years (mean±SD), respectively, with each group comprising 118 males and 28 females. The basal laboratory data, distribution of Child-Pugh class, HBeAg positivity (31.5% vs. 37.7%), HBV DNA level (5.74±2.35 vs. 5.98±2.29 log10 copies/mL), and proportion with a lifetime alcohol intake of more than 292 kg (30.8% vs. 34.9%) did not differ between cases and controls. The cumulative alcohol intake and the proportion of heavy drinkers did not differ between the two groups in male patients. Alcohol intake might not increase the risk of HCC in patients with HBV infection.