Primary structure of murine major histocompatibility alloantigens: amino acid sequence of the cyanogen bromide fragment Ia (positions 139-228) from the H-2Kb molecule.
Primary structure of murine major histocompatibility alloantigens: amino acid sequence of the cyanogen bromide fragment Ia (positions 139-228) from the H-2Kb molecule.
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鼠主要组织相容性同种抗原的一级结构：H-2Kb 分子的溴化氰片段 Ia（位置 139-228）的氨基酸序列。
DOI：
10.1021/bi00567a036
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发表时间：
1980
期刊：
影响因子：
2.9
通讯作者：
Coligan,JE
中科院分区：
文献类型：
--
作者：
Uehara,H;Ewenstein,BM;Martinko,JM;Nathenson,SG;Kindt,TJ;Coligan,JE
Lancet，D.，& Strominger，J. L.（1979）Biochemistry 18，5711]为68%，并且在H-2分子中作为第二碳水化合物部分的连接区的位置176、177和178处注意到差异。HLA-B7的该位置未检测到碳水化合物[Orr，. T.洛佩斯·德卡斯特罗Lancet，D.，& Strominger，J. L.（1979）Biochemistry 18，5711]，e经典的组织相容性抗原是鼠H-2主要组织相容性复合体（MHC）1的K、D和L区的多态性基因的产物[参见Klein（1975，1979），Snell et al.（1976）和Vitetta & Capra（1978）]。这些产物是含有约340个氨基酸的完整细胞表面糖蛋白（Schwartz et al.，1973），并且它们与β 2-微球蛋白（一种分子量为12000的多肽）结合存在于膜中（Rask等，1974;银& Hood，1974; Natori等人，1975年）。尽管这些抗原产物的主要功能仍不清楚，但最近的数据表明，它们在识别病毒诱导的抗原和其他细胞表面抗原中发挥作用，这一过程称为“关联识别”[参见Paul & Benacerraf（1977）、Shearer & Schmitt-Verhulst（1977）和Zinkernagel & Doherty（1979）的综述]。可能与它们在细胞识别中的假定作用有关的是K和D基因产物的显著多态性，这一性质首先在早期血清学分析中发现，
Lancet, D., & Strominger, J. L.(1979) Biochemistry 18, 5711] is 68%, and differences are noted at positions 176, 177, and 178 which in the H-2 molecule are the attachment region for a second carbohydrate moiety. No carbohydrate was detected in this position forHLA-B7 [Orr,. T. Lopez de Castro, J. A. Lancet, D., & Strominger, J. L.(1979) Biochemistry 18, 5711], e classical histocompatibility antigens are the products of the polymorphic genes at the K, D, and L regions of the murine H-2 major histocompatibility complex (MHC) 1 [see reviews by Klein (1975, 1979), Snell et al.(1976), and Vitetta & Capra (1978)]. These products are integral cell surface glycoproteins containing~ 340 amino acids (Schwartz et al., 1973), and they exist in the membrane in association with ß2-microglobulin, a polypeptide of molecular weight 12000 (Rask et al., 1974; Silver & Hood, 1974; Natori et al., 1975). Although the primary function of these antigenic products remains obscure, recent data suggest that they play a role in the recognition of virally induced and other cell surface an-tigens, in a process termed “associative recognition”[see re-views by Paul & Benacerraf (1977), Shearer & Schmitt-Verhulst (1977), and Zinkernagel & Doherty (1979)]. Possibly related to their postulated role in cell recognition is the remarkable polymorphism of the K and D gene products, a property first discovered in early serological analysis of