Physical activity mediates the association between personality and biomarkers of inflammation
Physical activity mediates the association between personality and biomarkers of inflammation
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DOI：
10.1177/2050312118774990
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发表时间：
2018-05-15
影响因子：
2.3
通讯作者：
Mroczek, Daniel K.
中科院分区：
文献类型：
--
作者：
Graham, Eileen K.;Bastarache, Emily D.;Mroczek, Daniel K.
目的：目前的研究调查是否人格特质和方面与白细胞介素-6，C-反应蛋白，和纤维蛋白原，以及是否体力活动介导的个性和生物标志物之间的关系inflammation.Methods：人格进行了评估，在美国的中年发展研究使用多维人格问卷和中年发展量表人格量表。数据来自960名参与者（平均年龄= 57.86岁，标准差=11.46）。2004年至2009年进行了人格评估。白细胞介素-6，纤维蛋白原和C-反应蛋白的血清水平进行了评估，在2005-2009年的一部分，中年发展在美国的生物标志物subproject.Results：较低的神经质与升高的白细胞介素-6，和成就与较低的纤维蛋白原。较高的体力活动与较低的白细胞介素-6和C反应蛋白相关。调解模型表明，体育活动介导的成就和白细胞介素-6和C-反应蛋白。讨论：体育活动是一个重要的因素，在健康行为模型的个性，并解释了一些个性和炎症之间的关联。这些发现通过将个体差异因素与炎症标志物联系起来，并表明这些过程可能部分通过特定行为（在这种情况下是身体活动）发挥作用，从而有助于衰老和健康领域。
Objectives: The current study investigated whether personality traits and facets were associated with interleukin-6, C-reactive protein, and fibrinogen, and whether physical activity mediated the relationship between personality and biomarkers of inflammation.Methods: Personality was assessed in the Midlife Development in the United States study using the Multi-Dimensional Personality Questionnaire and Midlife Development Inventory personality scale. Data were included from 960 participants (mean age=57.86years, standard deviation=11.46). Personality was assessed from 2004 to 2009. Serum levels of interleukin-6, fibrinogen, and C-reactive protein were assessed in 2005-2009 as part of the Midlife Development in the United States biomarkers subproject.Results: Lower neuroticism was associated with elevated interleukin-6, and achievement was associated with lower fibrinogen. Higher physical activity was associated with lower interleukin-6 and C-reactive protein. Mediation models suggested that physical activity mediated the associations between achievement and both interleukin-6 and C-reactive protein.Discussion: Physical activity is an important factor in the Health Behavior Model of personality and explains some of the associations between personality and inflammation. These findings contribute to the fields of aging and health by linking individual difference factors to markers of inflammation, and showing that these processes may function partially through specific behaviors, in this case physical activity.