Hsp27 as a Therapeutic Target in Cancers
Hsp27 as a Therapeutic Target in Cancers
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DOI：
10.2174/13894501113146660230
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发表时间：
2014-04-01
影响因子：
3.2
通讯作者：
Rocchi, Palma
中科院分区：
文献类型：
--
作者：
Acunzo, Julie;Andrieu, Claudia;Rocchi, Palma
热休克蛋白27（Heat shock protein 27，Hsp27）是一种由热休克、环境和病理生理应激诱导表达的蛋白质，具有蛋白伴侣和抗氧化作用。该蛋白在抑制细胞凋亡和肌动蛋白细胞骨架重塑中起主要作用。这种应激活化蛋白在许多癌症中上调，并且通过保护细胞免受通常诱导细胞凋亡的治疗剂的影响而与不良预后以及治疗抗性相关。本文综述了热休克蛋白27在癌症中的最新发现和作用，以及临床上靶向和抑制热休克蛋白27的不同策略。
Heat shock protein 27 (Hsp27), induced by heat shock, environmental and pathophysiological stressors, is a multidimensional protein that acts as a protein chaperone and an antioxidant. This protein plays a major role in the inhibition of apoptosis and actin cytoskeletal remodeling. This stress-activated protein is up-regulated in many cancers and is associated with poor prognosis as well as treatment resistance by protecting cells from therapeutic agent that normally induces apoptosis. This review highlights the most recent findings and role of Hsp27 in cancer and the different strategies to target and inhibit Hsp27 for clinical purposes.