Assessment of the Prodromal Questionnaire-Brief Child Version for Measurement of Self-reported Psychoticlike Experiences in Childhood
Assessment of the Prodromal Questionnaire-Brief Child Version for Measurement of Self-reported Psychoticlike Experiences in Childhood
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DOI：
10.1001/jamapsychiatry.2018.1334
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发表时间：
2018-08-01
期刊：
影响因子：
25.8
通讯作者：
Loewy, Rachel L.
中科院分区：
文献类型：
--
作者：
Karcher, Nicole R.;Barch, Deanna M.;Loewy, Rachel L.
儿童期精神病样经历（PLEs）与成年期诊断为精神障碍的几率更大有关。然而，没有已知的，有效的自我报告工具已被设计来测量儿童PLEs. ObjectiveTo检查的结构效度和心理测量学性质的一项措施的PLEs，前驱症状的简要儿童版本（PQ-BC）。设计，设置，和参与者这项验证研究使用的数据从第一波的青少年大脑和认知发展（ABCD）研究，一项前瞻性纵向研究，旨在评估从9至10岁到青春期后期和成年早期与不良身心健康结果相关的风险因素。ABCD数据集内的3984名儿童的基于人口的样本是从美国各地的20个研究地点招募的。本研究的数据收集时间为2016年6月1日至2017年8月31日。主要结果和指标分析了PQ-BC总分和痛苦评分在种族/民族和性别之间的测量不变性、其与PLE测量的关联以及其与PLE已知相关因素的关联，包括内化和外化症状、神经心理学测试表现、结果研究分析包括3984名参与者（1885名女孩[47.3%]和2099名男孩[52.7%];平均[SE]年龄，10.0 [0.01]岁）。结果证明了人种/种族和性别之间的测量不变性。精神障碍家族史与较高的平均（SE）PQ-BC总体相关（3.883 [0.352]; β = 0.061; 95%CI，0.027-0.094）和苦恼（10.210 [1.043]; β = 0.051; 95%CI，0.018-0.084）评分，而抑郁或躁狂家族史则无。较高的PQ-BC分数与较高的儿童评级内化症状率相关（总分：β范围，0.218 [95% CI，0.189-0.246]至0.273 [95% CI，0.245-0.301];痛苦评分：β范围，0.248 [95%CI，0.220-0.277]至0.310 [95%CI，0.281-0.338]），神经心理学测试表现缺陷，如工作记忆（总分：β = -0.042 [95% CI，-0.077至-0.008];痛苦评分：β = -0.051 [95% CI，-0.086至-0.017]），运动和语言发育里程碑延迟（总分：运动功能β = 0.057 [95% CI，0.026-0.086];言语功能β = 0.042 [95% CI，0.010-0.073];运动功能痛苦评分β = 0.048 [95% CI，0.017-0.079]; β = 0.049 [95%CI，0.018-0.081]）。结论和相关性这些结果为结构效度提供了支持，并证明了设计用于测量儿童PLEs的自我报告工具的足够的心理测量特性，提供了PQ-BC可能是精神障碍早期风险的有用测量的证据。此外，这些数据表明，在学龄的PLEs与许多相同的家庭，认知和情感因素与老年人群中的精神病症状，精神病的整个生命周期的维度一致。
IMPORTANCE Childhood psychoticlike experiences (PLEs) are associated with greater odds of a diagnosis of a psychotic disorder during adulthood. However, no known, well-validated self-report tools have been designed to measure childhood PLEs.OBJECTIVE To examine the construct validity and psychometric properties of a measure of PLEs, the Prodromal Questionnaire-Brief Child Version (PQ-BC).DESIGN, SETTING, AND PARTICIPANTS This validation study used data from the firstwave of the Adolescent Brain and Cognitive Development (ABCD) Study, a prospective longitudinal study aimed at assessing risk factors associated with adverse physical and mental health outcomes from ages 9 to 10 years into late adolescence and early adulthood. The population-based sample of 3984 children within the ABCD data set was recruited from 20 research sites across the United States. Data for this study were collected from June 1, 2016, through August 31, 2017.MAIN OUTCOMES AND MEASURES The PQ-BC Total and Distress scores were analyzed for measurement invariance across race/ethnicity and sex, their associations with measures of PLEs, and their associations with known correlates of PLEs, including internalizing and externalizing symptoms, neuropsychological test performance, and developmental milestones.RESULTS The study analyses included 3984 participants (1885 girls [47.3%] and 2099 boys [52.7%]; mean [SE] age, 10.0 [0.01] years). The results demonstrated measurement invariance across race/ethnicity and sex. A family history of psychotic disorder was associated with higher mean (SE) PQ-BC Total (3.883 [0.352]; beta = 0.061; 95% CI, 0.027-0.094) and Distress (10.210 [1.043]; beta = 0.051; 95% CI, 0.018-0.084) scores, whereas a family history of depression or mania was not. Higher PQ-BC scores were associated with higher rates of child-rated internalizing symptoms (Total score: beta range, 0.218 [95% CI, 0.189-0.246] to 0.273 [95% CI, 0.245-0.301]; Distress score: beta range, 0.248 [95% CI, 0.220-0.277] to 0.310 [95% CI, 0.281-0.338]), neuropsychological test performance deficits such as working memory (Total score: beta = -0.042 [95% CI, -0.077 to -0.008]; Distress score: beta = -0.051 [95% CI, -0.086 to -0.017]), and motor and speech developmental milestone delays (Total score: beta = 0.057 [95% CI, 0.026-0.086] for motor; beta = 0.042 [95% CI, 0.010-0.073] for speech; Distress score: beta = 0.048 [95% CI, 0.017-0.079] for motor; beta = 0.049 [95% CI, 0.018-0.081] for speech).CONCLUSIONS AND RELEVANCE These results provide support for the construct validity and demonstrate adequate psychometric properties of a self-report instrument designed to measure childhood PLEs, providing evidence that the PQ-BC may be a useful measure of early risk for psychotic disorders. Furthermore, these data suggest that PLEs at school age are associated with many of the same familial, cognitive, and emotional factors associated with psychotic symptoms in older populations, consistent with the dimensionality of psychosis across the lifespan.