The expression and localization of heme oxygenase in the adult guinea pig cochlea
The expression and localization of heme oxygenase in the adult guinea pig cochlea
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DOI：
10.1016/s0006-8993(02)04209-9
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发表时间：
2003-03
期刊：
影响因子：
2.9
通讯作者：
Kojiro Watanabe;T. Oshima;Toshimitsu Kobayashi;K. Ikeda
中科院分区：
文献类型：
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作者：
Kojiro Watanabe;T. Oshima;Toshimitsu Kobayashi;K. Ikeda
逆转录聚合酶链反应显示耳蜗中血红素加氧酶-1和血红素加氧酶-2 (HO-2) mRNA的表达，但前者被认为远低于后者。 HO-2样免疫反应性主要在柯蒂氏器和螺旋神经节细胞的支持细胞中观察到。然而，在耳蜗血管壁中几乎没有检测到免疫反应性。这些结果表明HO-2参与听觉神经传递和柯蒂氏器的微力学。
Reverse transcription-polymerase chain reaction demonstrated the expression of heme oxygenase-1 and heme oxygenase-2 (HO-2) mRNA in the cochlea, but the former was considered to be much lower than the latter. The HO-2-like immunoreactivity was observed mainly in supporting cells in the organ of Corti and in the spiral ganglion cells. However, in the vascular walls of the cochlea little immunoreactivity was detected. These results suggest that HO-2 is involved in the auditory neurotransmission and micromechanics of the organ of Corti.