2-BROMOETHYL GLYCOSIDES .4. 2-BROMOETHYL GLYCOSIDES IN GLYCOSIDE SYNTHESIS - PREPARATION OF GLYCOPROTEINS CONTAINING ALPHA-L-FUC-(1-]2)-D-GAL AND BETA-D-GAL-(1-]4)-D-GLCNAC
2-BROMOETHYL GLYCOSIDES .4. 2-BROMOETHYL GLYCOSIDES IN GLYCOSIDE SYNTHESIS - PREPARATION OF GLYCOPROTEINS CONTAINING ALPHA-L-FUC-(1-]2)-D-GAL AND BETA-D-GAL-(1-]4)-D-GLCNAC
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DOI：
10.1016/0008-6215(84)85159-9
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发表时间：
1984-01-01
影响因子：
3.1
通讯作者：
CARLSTROM, AS
中科院分区：
文献类型：
--
作者：
DAHMEN, J;FREJD, T;CARLSTROM, AS
2-溴乙基糖苷在碳水化合物合成中的适用性通过α-溴乙基糖苷的合成来证明。L-Fuc-（1 →）2）-D-Gal [血型H二糖]和β- D-Gal-（1 →）4）-D-GlcNAc。将溴乙基糖苷配基转化为甲氧基羰基乙基硫代乙基间隔基，这允许糖与蛋白质（牛血清白蛋白和钥孔血蓝蛋白）偶联。
The applicability of 2-bromoethyl glycosides in carbohydrate synthesis is demonstrated by the synthesis of glycosides of .alpha.-L-Fuc-(1 .fwdarw. 2)-D-Gal [blood group H disaccharide] and .beta.-D-Gal-(1 .fwdarw. 4)-D-GlcNAc. The bromoethyl aglycon was transformed into the methoxycarbonylethylthioethyl spacer, which allowed coupling of the sugars to proteins (bovine serum albumin and keyhole limpet hemocyanin).