Selective electrochemical detection of cysteine in complex serum by graphene nanoribbon.
Selective electrochemical detection of cysteine in complex serum by graphene nanoribbon.
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DOI：
10.1016/j.bios.2011.12.006
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发表时间：
2012-02
影响因子：
12.6
通讯作者：
Shuo Wu;Xiaoqin Lan;F. Huang;Zhengzi Luo;H. Ju;C. Meng;Chunying Duan
中科院分区：
文献类型：
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作者：
Shuo Wu;Xiaoqin Lan;F. Huang;Zhengzi Luo;H. Ju;C. Meng;Chunying Duan
Selective detection of cysteine in serum samples was achieved on a graphene nanoribbon (GNR) and Nafion nanocomposite modified electrode with high precision. The superior conductivity and abundant amount of active chemical oxygen groups on the edge of GNR led to extremely highly electrocatalytic activity of GNR towards the electrochemical oxidation of cysteine at +0.025V. The electrocatalytic behavior was further used for sensitive detection of cysteine by differential pulse voltammetry. Under optimized conditions, the calibration curve was linear in the range from 25nM to 500μM. The electrochemical sensor showed strong antifouling ability, good stability and selectivity. It could effectively exclude the interferences from other kinds of biothiols and the biological relevant species, thus had great perspective for in vivo analysis of biological samples.
