Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo.
Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo.
复制标题
肉豆蔻油通过抑制体内 COX-2 表达和 P 物质释放来缓解慢性炎症疼痛
DOI：
10.3402/fnr.v60.30849
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发表时间：
2016
影响因子：
3.3
通讯作者：
Wan CJ
中科院分区：
文献类型：
--
作者：
Zhang WK;Tao SS;Li TT;Li YS;Li XJ;Tang HB;Cong RH;Ma FL;Wan CJ
慢性疼痛，或有时被称为持续性疼痛，降低了患有慢性疾病如炎症性疾病、癌症和糖尿病的患者的生活质量。因此，草药引起了许多关注，并已被证明在治疗或缓解疼痛方面有效。在这项研究中，我们使用CFA注射大鼠作为可持续的疼痛模型，以测试肉豆蔻油的抗炎和镇痛作用，肉豆蔻油是一种香料风味添加剂，用于从肉豆蔻树的种子生产的饮料和烘焙食品。我们已经证明，肉豆蔻油可以通过抑制考克斯-2的表达和血液P物质水平来潜在地减轻CFA注射诱导的关节肿胀、机械异常性疼痛和热痛觉超敏，这使得肉豆蔻油有可能成为一种潜在的慢性疼痛缓解剂。
Chronic pain, or sometimes referred to as persistent pain, reduces the life quality of patients who are suffering from chronic diseases such as inflammatory diseases, cancer and diabetes. Hence, herbal medicines draw many attentions and have been shown effective in the treatment or relief of pain. Here in this study, we used the CFA-injected rats as a sustainable pain model to test the anti-inflammatory and analgesic effect of nutmeg oil, a spice flavor additive to beverages and baked goods produced from the seed of Myristica fragrans tree. We have demonstrated that nutmeg oil could potentially alleviate the CFA-injection induced joint swelling, mechanical allodynia and heat hyperanalgesia of rats through inhibition of COX-2 expression and blood substance P level, which made it possible for nutmeg oil to be a potential chronic pain reliever.