Research Priorities in the Area of Sleep/Circadian Rhythm and Aging Research: Commentary on "Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Sleep, Circadian Rhythms, and Aging:
Research Priorities in the Area of Sleep/Circadian Rhythm and Aging Research: Commentary on "Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Sleep, Circadian Rhythms, and Aging:
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睡眠/昼夜节律和衰老研究领域的研究重点：对“美国老年医学会和国家老龄化研究所关于睡眠、昼夜节律和衰老的床边到工作台会议的报告和研究议程”的评论：
DOI：
10.1093/sleep/zsx065
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发表时间：
2017
期刊：
影响因子：
5.6
通讯作者：
Veasey,SigridC
中科院分区：
文献类型：
--
作者：
Fung,ConstanceH;Veasey,SigridC
Currently, over 50 million individuals in the United States are 65 years or older. Sleep and circadian disturbances (SCD) are prevalent in older individuals. Despite a tremendous amount of research characterizing sleep/circadian rhythms across aging research, key mechanisms underlying the disturbances are poorly understood.One of the fundamental challenges in understanding mechanisms underlying SCD in aging is that so many aspects of health and disease influence these processes in older individuals. For this reason, the National Institute on Aging and the American Geriatrics Society, with generous support from other groups, orchestrated a multi-disciplinary conference (October 4 to 6, 2015) that brought together both established and early basic, clinical, and health services research investigators who study the many aspects of nocturnal disruptions in older adults. Organizers acquired information about “gaps in knowledge” from the conference faculty and other participants prior to the conference. At the end of the conference and after much discussion, several faculty members re-addressed the “gaps in knowledge” in the context of information gained from the diverse presentations, and drafted a white paper, which summarizes what is known regarding SCD in older adults and identifies important questions to address. 1 For our field, the conference was immensely successful in several notable directions. During the conference, faculty provided an important “forest” overview of SCD in older adults, conceptualizing it as a geriatric syndrome (ie, a “multifactorial health condition that occurs when the accumulated effects of impairments in multiple systems renders a person vulnerable to situation challenges” 2). Specific changes in SCD that occur with advanced age, diseases, environmental exposures, and medications may contribute to the development of SCD. Further phenotyping and better understanding of how the temporal progression of SCD may be altered are needed. Key research questions raised during the conference included questions such as “what is normal healthy aging of sleep” and “how does the need for sleep change with aging?”
