SynBioSuite: A Tool for Improving the Workflow for Genetic Design and Modeling
SynBioSuite: A Tool for Improving the Workflow for Genetic Design and Modeling
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DOI：
10.1021/acssynbio.2c00597
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发表时间：
2023-03-08
影响因子：
4.7
通讯作者：
Myers，Chris J.
中科院分区：
文献类型：
--
作者：
Sents，Zachary;Stoughton，Thomas E.;Myers，Chris J.
合成生物学研究导致了许多软件工具的开发，用于设计、构建、编辑、模拟和共享遗传部件和电路。这些工具包括SBOLCanvas、iBioSim和SynBioHub，它们可以结合使用来创建遵循设计-构建-测试-学习过程的遗传电路设计。然而，尽管自动化在这些工具中工作，但这些软件工具中的大多数都没有集成，并且它们之间传输信息的过程是一个非常手动的、容易出错的过程。为了解决这个问题，这项工作自动化了其中的一些过程，并提出了SynBioSuite，这是一个基于云的工具，通过应用编程接口自动设置和接收用于模拟设计的遗传电路的结果，消除了当前方法的许多缺点。
Synthetic biology research has led to the development of many software tools for designing, constructing, editing, simulating, and sharing genetic parts and circuits. Among these tools are SBOLCanvas, iBioSim, and SynBioHub, which can be used in conjunction to create a genetic circuit design following the design–build–test–learn process. However, although automation works within these tools, most of these software tools are not integrated, and the process of transferring information between them is a very manual, error-prone process. To address this problem, this work automates some of these processes and presents SynBioSuite, a cloud-based tool that eliminates many of the drawbacks of the current approach by automating the setup and reception of results for simulating a designed genetic circuit via an application programming interface.