New circulating genomic variant of Crimean-Congo hemorrhagic fever virus in Iran
New circulating genomic variant of Crimean-Congo hemorrhagic fever virus in Iran
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DOI：
10.1007/s00705-012-1588-0
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发表时间：
2013-05-01
影响因子：
2.7
通讯作者：
Mostafavi, Ehsan
中科院分区：
文献类型：
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作者：
Chinikar, Sadegh;Shah-Hosseini, Nariman;Mostafavi, Ehsan
克里米亚-刚果出血热是由克里米亚-刚果出血热病毒(CCHFV)引起的一种病毒感染。2012年5月27日，一名女子因不小心将牛血溅入眼睛而患病。对患者的血清进行了血清学和分子检测。血清学检测结果为阴性，但RT-PCR检测CCHFV呈强阳性。对CCHFV基因组序列的系统发育研究表明，它与俄罗斯毒株的520个碱基区有50%的相似性。通过结合历史系统发育数据和当前数据，可以推测伊朗可能存在五种以上的CCHFV基因组变异。
Crimean-Congo hemorrhagic fever is a viral infection that is caused by Crimean-Congo hemorrhagic fever virus (CCHFV). On May 27, 2012, a woman became ill after accidentally splashing cow's blood into her eyes. Serological and molecular investigations were carried out on the serum of the patient. The test results for serological testing were negative, but RT-PCR was strongly positive for CCHFV. A phylogenetic study on the CCHFV genome sequence showed 50 % similarity to a 520-bp region of Russian strains. By combining historical phylogenetic data and current data, it can be surmised that there are potentially more than five circulating CCHFV genomic variants in Iran.