Histamine-releasing factor: a promising therapeutic target for food allergy.
Histamine-releasing factor: a promising therapeutic target for food allergy.
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DOI：
10.1172/jci98297
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发表时间：
2017-12
期刊：
影响因子：
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通讯作者：
M. Wills-Karp
中科院分区：
文献类型：
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作者：
M. Wills-Karp
在过去的几十年里，食物过敏的患病率以惊人的速度增加。尽管疾病患病率急剧增加，但有效疗法的开发却未能跟上。在本期 JCI 中，Ando 等人。在小鼠模型中提供组胺释放因子 (HRF) 与 IgE 相互作用与食物过敏之间的因果关系。对鸡蛋过敏的人类患者和食物过敏的小鼠的成功口服免疫疗法与 HRF 反应性 IgE 水平的持续抑制有关。这些结果支持 HRF-IgE 相互作用在肠道炎症放大中的作用，并表明 HRF 作为食物过敏的治疗靶点。
The prevalence of food allergies has been increasing at an alarming rate over the last few decades. Despite the dramatic increase in disease prevalence, the development of effective therapies has not kept pace. In this issue of the JCI, Ando et al. provide a causal link between histamine-releasing factor (HRF) interactions with IgE and food allergy in a murine model. Successful oral immunotherapy of both egg-allergic human patients and food-allergic mice was associated with sustained suppression of HRF-reactive IgE levels. These results support a role for HRF-IgE interactions in the amplification of intestinal inflammation and suggest HRF as a therapeutic target in food allergy.