Neutrophils of Centenarians Show Function Levels Similar to Those of Young Adults
Neutrophils of Centenarians Show Function Levels Similar to Those of Young Adults
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DOI：
10.1111/j.1532-5415.2008.02018.x
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发表时间：
2008-12-01
影响因子：
6.3
通讯作者：
de la Fuente, Monica
中科院分区：
文献类型：
--
作者：
Alonso-Fernandez, Patricia;Puerto, Marta;de la Fuente, Monica
分析健康百岁老人外周血中性粒细胞的几种功能和抗氧化参数（男女）并与健康的年轻人进行比较（25-35岁）和中年（65-75岁）男性和女性。横断面研究。以社区为基础。21名健康百岁老人（8名男性），30名年轻人（15名男性），和30名中年成人（15名男性）。（粘附、趋化性、吞噬作用，以及刺激和非刺激的细胞内超氧阴离子水平）和抗氧化剂参数在三个研究组中测量外周血中性粒细胞悬液中的谷胱甘肽水平和过氧化氢酶活性。老年组比青壮年和百岁老人差（趋化性和吞噬作用较低，粘附性和超氧阴离子水平较高）。百岁老人的中性粒细胞功能更接近年轻人。除细胞内超氧阴离子水平在年轻成年女性中低于年轻成年男性外，男性和女性中性粒细胞功能中与糖尿病相关的差异基本相似。随着正常衰老，总谷胱甘肽水平下降，但这项研究中的百岁老人显示出与年轻人相似的水平。百岁老人的过氧化氢酶活性是三组中最高的。随着年龄的增长，免疫系统逐渐受损。百岁老人中性粒细胞功能和抗氧化系统的更好保存可能在这些受试者的长寿中发挥关键作用。
To analyze several functions and antioxidant parameters of peripheral blood neutrophils from healthy centenarians (men and women) and compare them with those of healthy young (aged 25-35) and middle-aged (aged 65-75) men and women.Cross-sectional study.Community-based.Twenty-one healthy centenarians (8 men), 30 young adults (15 men), and 30 middle-aged adults (15 men).Several neutrophil functions (adherence, chemotaxis, phagocytosis, and stimulated and nonstimulated intracellular superoxide anion levels) and antioxidant parameters (glutathione levels and catalase activity) were measured in peripheral blood neutrophil suspension in the three study groups.Neutrophil functions of the middle-aged group were worse than those of young adults and centenarians (lower chemotaxis and phagocytosis and higher adherence and superoxide anion levels). The neutrophil functions of the centenarians were closer to those of the young adults. Age-related differences in neutrophil functions were fundamentally similar in men and women, except for intracellular superoxide anion levels, which were lower in young adult women than in young adult men. With normal aging, total glutathione levels decrease, but the centenarians in this study showed levels similar to those of young adults. Centenarians showed the highest catalase activity of the three groups.Progressive impairment of the immune system accompanies aging. The better preservation of function and antioxidant systems in the neutrophils of centenarians could play a key role in the longevity of these subjects.