Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues.
Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues.
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DOI：
10.1016/j.envint.2015.12.002
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发表时间：
2016-03
影响因子：
11.8
通讯作者：
Stapleton HM
中科院分区：
文献类型：
--
作者：
Leonetti C;Butt CM;Hoffman K;Miranda ML;Stapleton HM
遗留的环境污染物，如多溴联苯醚（PBDEs）在人体组织中被广泛检测到。然而，很少有研究测量胎盘组织中的多溴二苯醚，也没有报告测量胎盘组织中的2，4，6-三溴苯酚（2，4，6-TBP）。这些污染物的测量对于了解潜在的胎儿暴露是重要的，因为这些化合物已被证明会改变体外和体内甲状腺激素调节。在这项研究中，我们测量了2010-2011年间在美国北卡罗来纳州达勒姆县收集的102份人类胎盘组织中的一系列多溴二苯醚和2，4，6-TBP。检测到的最丰富的多溴二苯醚同系物是BDE-47，平均浓度为5.09纳克/克脂质（范围：0.12-141纳克/克脂质;检测频率为91%）;然而，2，4，6-TBP普遍存在，浓度较高，平均浓度为15.4纳克/克脂质（范围：1.31-316纳克/克脂质;检测频率为100%）。在超过50%的样本中也检测到了BDE-209，并且与胎盘组织中的2，4，6-TBP存在显著关联，这表明它们可能有类似的来源，或者2，4，6-TBP可能是BDE-209的降解产物。有趣的是，BDE-209和2，4，6-TBP与年龄呈负相关（分别为rs=-0.16; p=0.10和rs=-0.17; p=0.08）。这项工作的结果表明，多溴联苯醚和2，4，6-三丁基苯酚在人类胎盘组织中具有生物累积性，可能导致产前接触这些环境污染物。未来的研究需要确定这些联合暴露是否与婴儿和儿童的任何不良健康措施有关。
Legacy environmental contaminants such as polybrominated diphenyl ethers (PBDEs) are widely detected in human tissues. However, few studies have measured PBDEs in placental tissues, and there are no reported measurements of 2,4,6-tribromophenol (2,4,6-TBP) in placental tissues. Measurements of these contaminants are important for understanding potential fetal exposures, as these compounds have been shown to alter thyroid hormone regulation in vitro and in vivo. In this study, we measured a suite of PBDEs and 2,4,6-TBP in 102 human placental tissues collected between 2010–2011 in Durham County, North Carolina, USA. The most abundant PBDE congener detected was BDE-47, with a mean concentration of 5.09 ng/g lipid (range: 0.12–141 ng/g lipid; detection frequency 91%); however, 2,4,6-TBP was ubiquitously detected and present at higher concentrations with a mean concentration of 15.4 ng/g lipid (range:1.31–316 ng/g lipid; detection frequency 100%). BDE-209 was also detected in more than 50% of the samples, and was significantly associated with 2,4,6-TBP in placental tissues, suggesting they may have a similar source, or that 2,4,6-TBP may be a degradation product of BDE-209. Interestingly, BDE-209 and 2,4,6-TBP were negatively associated with age (rs=−0.16; p=0.10 and rs=−0.17; p=0.08, respectively). The results of this work indicate that PBDEs and 2,4,6-TBP bioaccumulate in human placenta tissue and likely contribute to prenatal exposures to these environmental contaminants. Future studies are needed to determine if these joint exposures are associated with any adverse health measures in infants and children.