SENSATION SEEKING AMONGST HEALTHY-VOLUNTEERS PARTICIPATING IN PHASE-I CLINICAL-TRIALS
SENSATION SEEKING AMONGST HEALTHY-VOLUNTEERS PARTICIPATING IN PHASE-I CLINICAL-TRIALS
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DOI：
10.1111/j.1365-2125.1995.tb04469.x
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发表时间：
1995-04-01
影响因子：
3.4
通讯作者：
CAMI, J
中科院分区：
文献类型：
--
作者：
FARRE, M;LAMAS, X;CAMI, J
1期临床试验通常在健康志愿者中进行。除了经济利益，可能影响参与意愿的因素还包括科学兴趣、好奇心和对高风险活动的选择。2我们评估了人格变量与临床药理学研究志愿服务之间的关系。采用感觉寻求量表(SSS)和艾森克人格问卷(EPQ)对48名自愿参加I期临床试验的健康男大学生和43名不愿参加I期临床试验的男大学生进行问卷调查。3健康志愿者与不情愿志愿者在刺激冒险(7.9vs6.7，P=0.0034)、体验寻求(6.4vs5.2，P=0.0012)、去抑制(6.2vs4.3，P<；0.0001)、无聊易感性(3.9vs2.8，P=0.0073)、总感觉寻求特质(24.3vs19.0，P<；)上存在显著差异；0.0001)、外倾性(15.1vs13.3，P=0.0490)、精神质(4.4vs3.5，P=0.0086)。健康志愿者与一般常模比较，除乏味易感性和精神病性外，其余各维度均有统计学意义。4.与不愿参与I期临床试验和一般常模的人相比，健康志愿者的人格特征具有更高的感觉寻求特质和外向性。
1 Phase I clinical trials are usually carried out in healthy volunteers. In addition to economic gain, factors that may influence willingness to participate include scientific interest, curiosity and choice for risky activities.2 We assessed the relationship between personality variables and volunteering for clinical pharmacology research. Two personality questionnaires, the Sensation Seeking Scale (SSS, form V) and the Eysenck Personality Questionnaire (EPQ), were administered to 48 male healthy university students who volunteered to participate in a phase I clinical trial and to 43 male university students who were not willing to participate in phase I clinical trials. General norm data were also used for the comparison of results.3 When healthy volunteers were compared with unwilling subjects, significant differences were found in thrill-and-adventure seeking (7.9 vs 6.7, P = 0.0034), experience seeking (6.4 vs 5.2, P = 0.0012), disinhibition (6.2 vs 4.3, P < 0.0001), boredom susceptibility (3.9 vs 2.8, P = 0.0073), total sensation seeking trait (24.3 vs 19.0, P < 0.0001), extraversion (15.1 vs 13.3, P = 0.0490), and psychoticism (4.4 vs 3.5, P = 0.0086). When healthy volunteers were compared with general norm data similar statistically significant differences were found in all these scales, except for boredom susceptibility and psychoticism.4 The personality profile of healthy volunteers was characterized by a higher sensation seeking trait and extraversion as compared with individuals who were not willing to participate in phase I clinical trials and general norm data.