The road to discovery of neuronal nicotinic cholinergic receptor subtypes.
The road to discovery of neuronal nicotinic cholinergic receptor subtypes.
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DOI：
10.1007/978-3-540-69248-5_4
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发表时间：
2009-01-01
影响因子：
--
通讯作者：
Grady, Sharon R
中科院分区：
文献类型：
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作者：
Collins, Allan C;Salminen, Outi;Grady, Sharon R
哺乳动物脑表达9种不同烟碱胆碱能受体亚单位（α 2-α 7，β 2-β 4）的mRNAs，这些亚单位在非洲爪蟾卵母细胞中表达时形成功能性受体，这一发现表明许多不同类型的烟碱胆碱能受体（nAChRs）可能在哺乳动物脑中表达。使用历史的方法，本章回顾了一些进展，在确定的nAChR亚型，似乎发挥了至关重要的作用，在调节多巴胺能功能。在多巴胺神经元中表达的nAChR亚型，以及与多巴胺神经元相互作用的神经元（多巴胺能，GABA能），是本文的重点。突出显示的主题包括低亲和力α 4 β 2 * nAChR的发现，最近表征的α 6 * nAChR的身份，以及发现这些α 6 * 受体对迄今为止表征的任何天然受体的受体激活具有最高亲和力。被忽视的主题，在其他最近的审查这一领域，如替代成绩单的发现和潜在的重要性，沿着讨论其潜在的重要性。
The discovery that mammalian brain expresses the mRNAs for nine different nicotinic cholinergic receptor subunits (alpha2-alpha7, beta2-beta4) that form functional receptors when expressed in Xenopus laevis oocytes suggests that many different types of nicotinic cholinergic receptors (nAChRs) might be expressed in the mammalian brain., Using an historical approach, this chapter reviews some of the progress made in identifying the nAChR subtypes that seem to play a vital role in modulating dopaminergic function. nAChR subtypes that are expressed in dopamine neurons, as well as neurons that interact with dopamine neurons (glutamatergic, GABAergic), serve as the focus of this review. Subjects that are highlighted include the discovery of a low affinity alpha4beta2* nAChR, the identity of recently characterized alpha6* nAChRs, and the finding that these alpha6* receptors have the highest affinity for receptor activation of any of the native receptors that have been characterized to date. Topics that have been ignored in other recent reviews of this area, such as the discovery and potential importance of alternative transcripts, are presented along with a discussion of their potential importance.